高碘酸盐氧化的NADP⁺是人类胎盘雌二醇-17β脱氢酶的强效抑制剂。
Periodate-oxidized NADP+ is a powerful inhibitor of human placental estradiol-17 beta dehydrogenase.
作者信息
Mendoza-Hernández G, López-Solache I, Díaz-Zagoya J C
出版信息
Biochem Biophys Res Commun. 1987 Jul 31;146(2):645-51. doi: 10.1016/0006-291x(87)90577-8.
Periodate-oxidized NADP+ inhibits the NAD+-linked activity of human placental estradiol-17 beta dehydrogenase (EC 1.1.1.62). The inhibition appears to be competitive with respect to NAD+ and can be reversed by dialysis or gel filtration. The apparent inhibitor constant for the periodate-oxidized analogue is 0.047 microM. The presence in the incubation mixture of NAD+ protects the enzyme against inhibition. No inhibitory effects of the coenzyme analogue are observed on the NADP+-linked activity of the enzyme.
高碘酸盐氧化的NADP⁺抑制人胎盘雌二醇-17β脱氢酶（EC 1.1.1.62）的NAD⁺连接活性。这种抑制作用似乎对NAD⁺具有竞争性，并且可以通过透析或凝胶过滤来逆转。高碘酸盐氧化类似物的表观抑制常数为0.047微摩尔。孵育混合物中NAD⁺的存在可保护该酶免受抑制。未观察到辅酶类似物对该酶的NADP⁺连接活性有抑制作用。
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