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白细胞介素2与淋巴因子激活的杀伤细胞治疗儿童原发性肝细胞癌——初步报告

Interleukin 2 and lymphokine-activated killer cells in the treatment of childhood primary hepatocellular carcinoma--a preliminary report.

作者信息

Hsieh K H, Chang J S, Wu H L, Chu C T

出版信息

Asian Pac J Allergy Immunol. 1987 Jun;5(1):13-6.

PMID:3040030
Abstract

Recombinant interleukin-2 (RIL-2) and lymphokine-activated killer (LAK) cells were administered to 2 boys with the end-stage of primary hepatocellular carcinoma (HCC); the efficacy and toxicity were evaluated. Immunologically, the natural killer and LAK activities were enhanced. Clinically, the side effects were similar to those reported for adults but milder. This kind of treatment may be considered for children with the early stages of hepatocellular carcinoma.

摘要

将重组白细胞介素-2(RIL-2)和淋巴因子激活的杀伤细胞(LAK)用于2例原发性肝细胞癌(HCC)终末期男孩,评估其疗效和毒性。免疫方面,自然杀伤活性和LAK活性增强。临床方面,副作用与成人报道的相似,但较轻。对于早期肝细胞癌患儿可考虑这种治疗方法。

相似文献

1
Interleukin 2 and lymphokine-activated killer cells in the treatment of childhood primary hepatocellular carcinoma--a preliminary report.白细胞介素2与淋巴因子激活的杀伤细胞治疗儿童原发性肝细胞癌——初步报告
Asian Pac J Allergy Immunol. 1987 Jun;5(1):13-6.
2
Immunotherapy of hepatocellular carcinoma with autologous lymphokine-activated killer cells and/or recombinant interleukin-2.用自体淋巴因子激活的杀伤细胞和/或重组白细胞介素-2对肝细胞癌进行免疫治疗。
J Cancer Res Clin Oncol. 1988;114(3):283-90. doi: 10.1007/BF00405835.
3
Adoptive immunotherapy of murine hepatic metastases with lymphokine activated killer (LAK) cells and recombinant interleukin 2 (RIL 2) can mediate the regression of both immunogenic and nonimmunogenic sarcomas and an adenocarcinoma.用淋巴因子激活的杀伤细胞(LAK)和重组白细胞介素2(RIL-2)对小鼠肝转移瘤进行过继性免疫治疗,可介导免疫原性和非免疫原性肉瘤以及一种腺癌的消退。
J Immunol. 1985 Dec;135(6):4273-80.
4
Adoptive immunotherapy with lymphokine-activated killer cells plus recombinant interleukin 2 in patients with unresectable hepatocellular carcinoma.采用淋巴因子激活的杀伤细胞加重组白细胞介素2对无法切除的肝细胞癌患者进行过继性免疫治疗。
Hepatology. 1989 Sep;10(3):349-53. doi: 10.1002/hep.1840100318.
5
Lysis of primary hepatic tumours by lymphokine activated killer cells.淋巴因子激活的杀伤细胞对原发性肝肿瘤的溶解作用。
Gut. 1987 Feb;28(2):117-24. doi: 10.1136/gut.28.2.117.
6
Treatment of hepatocellular carcinoma utilizing lymphokine-activated killer cells and interleukin-2.利用淋巴因子激活的杀伤细胞和白细胞介素-2治疗肝细胞癌。
Cancer Chemother Pharmacol. 1989;23 Suppl:S45-8. doi: 10.1007/BF00647239.
7
Intratumoral echo-guided injection of interleukin-2 and lymphokine-activated killer cells in hepatocellular carcinoma.肝细胞癌瘤内回声引导下注射白细胞介素-2和淋巴因子激活的杀伤细胞
Hepatogastroenterology. 1989 Oct;36(5):352-6.
8
The anti-tumor efficacy of lymphokine-activated killer cells and recombinant interleukin 2 in vivo: direct correlation between reduction of established metastases and cytolytic activity of lymphokine-activated killer cells.淋巴因子激活的杀伤细胞和重组白细胞介素2在体内的抗肿瘤疗效:已形成转移灶的减少与淋巴因子激活的杀伤细胞的细胞溶解活性之间的直接相关性。
J Immunol. 1986 May 15;136(10):3899-909.
9
Combined therapy of mice bearing a lymphokine-activated killer-resistant tumor with recombinant interleukin 2 and an antitumor monoclonal antibody capable of inducing antibody-dependent cellular cytotoxicity.用重组白细胞介素2和一种能够诱导抗体依赖性细胞毒性的抗肿瘤单克隆抗体对携带抗淋巴因子激活的杀伤细胞肿瘤的小鼠进行联合治疗。
Cancer Res. 1988 Mar 1;48(5):1173-9.
10
[Changes in lymphokine-activated killer cell (LAK) activity in patients with hepatocellular carcinoma after transcatheter arterial embolization].[经导管动脉栓塞术后肝细胞癌患者淋巴因子激活的杀伤细胞(LAK)活性的变化]
Nihon Shokakibyo Gakkai Zasshi. 1986 Dec;83(12):2638.

引用本文的文献

1
Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic approaches.自然杀伤细胞在肝细胞癌中的作用:现状与未来免疫治疗方法的展望。
Front Med. 2017 Dec;11(4):509-521. doi: 10.1007/s11684-017-0546-3. Epub 2017 Aug 5.