Shekhter A B, Berchenko G N, Nikolaev A V
Biull Eksp Biol Med. 1977 May;83(5):627-30.
The role of macrophages in the resorption of denatured collagen in the wound tissue was demonstrated by transmission and scanning electron microscopy investigation. Tight cell contacts between the macrophages and fibroblasts in the granulation tissue preceded active collagen synthesis and fibrillogenesis. A hypothesis was suggested according to which these contacts played an important role in the transfer of specific signals for the initiation of collagen biosynthesis; collagen decomposition products were considered as the actual signals, thus connecting the collagen catabolism and biosynthesis. Such a feed-back mechanism probably served as an integral part of the general hemostasis regulating the growth of connective tissue.
通过透射电子显微镜和扫描电子显微镜研究证实了巨噬细胞在伤口组织中变性胶原蛋白吸收过程中的作用。肉芽组织中巨噬细胞与成纤维细胞之间紧密的细胞接触先于活跃的胶原蛋白合成和纤维形成。提出了一种假说，即这些接触在传递启动胶原蛋白生物合成的特定信号中起重要作用；胶原蛋白分解产物被认为是实际信号，从而将胶原蛋白分解代谢与生物合成联系起来。这种反馈机制可能是调节结缔组织生长的一般止血过程的一个组成部分。
