暴露于二氧化硅粉尘的豚鼠灌洗液的溶酶体酶活性和成纤维细胞刺激作用。
Lysosomal enzyme activity and fibroblast stimulation of lavage from guinea pigs exposed to silica dust.
作者信息
Sjöstrand M, Rylander R
出版信息
Br J Exp Pathol. 1987 Jun;68(3):309-18.
Abstract
Guinea pigs were exposed to silica dust for 3 weeks and examined up to 1 year thereafter. The activity of several lysosomal enzymes in lung lavage fluid (LLF) increased from 8 weeks after cessation of exposure whereas the level in aveolar macrophages decreased. Collagen synthesis in fibroblast cultures exposed to LLF was also increased except at 24 weeks after exposure. The results indicate that 8 weeks and later after cessation of exposure to silica dust there are cellular changes in the lung which can be related to the exposure, although typical silicotic lesions were not observed till 1 year after the exposure.
摘要
将豚鼠暴露于二氧化硅粉尘中3周，此后持续观察1年。暴露停止后8周起，肺灌洗液（LLF）中几种溶酶体酶的活性增加，而肺泡巨噬细胞中的酶水平降低。暴露于LLF的成纤维细胞培养物中的胶原蛋白合成也增加，但暴露后24周时除外。结果表明，暴露停止8周及以后，肺部出现了与暴露相关的细胞变化，尽管直到暴露后1年才观察到典型的矽肺病变。
相似文献
1
Lysosomal enzyme activity and fibroblast stimulation of lavage from guinea pigs exposed to silica dust.暴露于二氧化硅粉尘的豚鼠灌洗液的溶酶体酶活性和成纤维细胞刺激作用。
Br J Exp Pathol. 1987 Jun;68(3):309-18.
2
Enzymes in lung lavage fluid after inhalation exposure to silica dust.
Environ Res. 1984 Apr;33(2):307-11. doi: 10.1016/0013-9351(84)90028-8.
3
Lung cell reactions in guinea pigs exposed to tobacco smoke and silica dust or bacterial lipopolysaccharides.
Toxicology. 1984 Feb;29(4):271-80. doi: 10.1016/0300-483x(84)90159-8.
4
Free lung cell phagocytosis and lysosomal enzyme activity after inhalation of lipopolysaccharide in guinea-pigs.豚鼠吸入脂多糖后肺细胞的吞噬作用及溶酶体酶活性
Agents Actions. 1985 Jul;16(5):353-8. doi: 10.1007/BF01982872.
5
6
Pulmonary macrophage phagocytosis and enzyme production after in vivo exposure to silica dust.体内暴露于二氧化硅粉尘后肺巨噬细胞的吞噬作用和酶产生
Toxicol Appl Pharmacol. 1983 Mar 30;68(1):152-9. doi: 10.1016/0041-008x(83)90364-2.
7
NTP Toxicology and Carcinogenesis Studies of Talc (CAS No. 14807-96-6)(Non-Asbestiform) in F344/N Rats and B6C3F1 Mice (Inhalation Studies).滑石（CAS编号：14807-96-6）（非石棉状）在F344/N大鼠和B6C3F1小鼠中的NTP毒理学和致癌性研究（吸入研究）
Natl Toxicol Program Tech Rep Ser. 1993 Sep;421:1-287.
8
The effects of silica dust and alveolar macrophages on lung fibroblasts grown in vitro.
Life Sci. 1974 Jan 16;14(2):355-64. doi: 10.1016/0024-3205(74)90066-6.
9
Silica-induced apoptosis in mouse alveolar macrophages is initiated by lysosomal enzyme activity.二氧化硅诱导的小鼠肺泡巨噬细胞凋亡是由溶酶体酶活性引发的。
Toxicol Sci. 2004 Jul;80(1):34-48. doi: 10.1093/toxsci/kfh121. Epub 2004 Mar 31.
10
Regulation of lung fibroblast proliferation and collagen synthesis by alveolar macrophages in experimental silicosis. I: Effect of macrophage conditioned medium from silica instilled rats.实验性矽肺中肺泡巨噬细胞对肺成纤维细胞增殖和胶原合成的调节。I：来自二氧化硅注入大鼠的巨噬细胞条件培养基的作用。
J Environ Pathol Toxicol Oncol. 1986 Sep-Dec;7(1-2):87-97.
引用本文的文献
1
Pulmonary inflammation induced by repeated inhalations of beta(1,3)-D-glucan and endotoxin.反复吸入β(1,3)-D-葡聚糖和内毒素引起的肺部炎症。
Int J Exp Pathol. 1994 Apr;75(2):85-90.
2
3
Enzyme activities of lung lavage in silicosis.
Lung. 1990;168(3):151-8. doi: 10.1007/BF02719686.
4
Extracellular matrix components in bronchoalveolar lavage fluid in quartz exposed rats.石英暴露大鼠支气管肺泡灌洗液中的细胞外基质成分
Br J Ind Med. 1991 Nov;48(11):776-82. doi: 10.1136/oem.48.11.776.
本文引用的文献
1
Pulmonary effects of inhalation of titanium dioxide by rats.大鼠吸入二氧化钛的肺部效应。
Am Ind Hyg Assoc J. 1963 Jan-Feb;24:42-6. doi: 10.1080/00028896309342922.
2
Enzymes in lung lavage fluid after inhalation exposure to silica dust.
Environ Res. 1984 Apr;33(2):307-11. doi: 10.1016/0013-9351(84)90028-8.
3
Pulmonary macrophage phagocytosis and enzyme production after in vivo exposure to silica dust.体内暴露于二氧化硅粉尘后肺巨噬细胞的吞噬作用和酶产生
Toxicol Appl Pharmacol. 1983 Mar 30;68(1):152-9. doi: 10.1016/0041-008x(83)90364-2.
4
Bronchopulmonary humoral and cellular enhancement in experimental silicosis.实验性矽肺中支气管肺体液和细胞的增强作用
J Reticuloendothel Soc. 1981 Feb;29(2):153-61.
5
Liberation of a fibrogenic factor from human blood monocytes, ascites cells, cultured histiocytes and transformed mouse macrophages by treatment with SiO2.通过用二氧化硅处理从人血单核细胞、腹水细胞、培养的组织细胞和转化的小鼠巨噬细胞中释放出一种纤维化因子。
Scand J Clin Lab Invest. 1980 Jun;40(4):311-8. doi: 10.3109/00365518009092649.
6
Biological effects and toxicity assessment of titanium dioxides: anatase and rutile.
Am Ind Hyg Assoc J. 1985 Feb;46(2):69-72. doi: 10.1080/15298668591394419.
7
Biological activity of titanium dioxides.
Int Arch Occup Environ Health. 1979 Apr 20;43(2):93-7. doi: 10.1007/BF00378147.
Zotero 插件