暴露于二氧化硅粉尘的豚鼠灌洗液的溶酶体酶活性和成纤维细胞刺激作用。
Lysosomal enzyme activity and fibroblast stimulation of lavage from guinea pigs exposed to silica dust.
作者信息
Sjöstrand M, Rylander R
出版信息
Br J Exp Pathol. 1987 Jun;68(3):309-18.
Abstract
Guinea pigs were exposed to silica dust for 3 weeks and examined up to 1 year thereafter. The activity of several lysosomal enzymes in lung lavage fluid (LLF) increased from 8 weeks after cessation of exposure whereas the level in aveolar macrophages decreased. Collagen synthesis in fibroblast cultures exposed to LLF was also increased except at 24 weeks after exposure. The results indicate that 8 weeks and later after cessation of exposure to silica dust there are cellular changes in the lung which can be related to the exposure, although typical silicotic lesions were not observed till 1 year after the exposure.
摘要
将豚鼠暴露于二氧化硅粉尘中3周，此后持续观察1年。暴露停止后8周起，肺灌洗液（LLF）中几种溶酶体酶的活性增加，而肺泡巨噬细胞中的酶水平降低。暴露于LLF的成纤维细胞培养物中的胶原蛋白合成也增加，但暴露后24周时除外。结果表明，暴露停止8周及以后，肺部出现了与暴露相关的细胞变化，尽管直到暴露后1年才观察到典型的矽肺病变。
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本文引用的文献
1
Pulmonary effects of inhalation of titanium dioxide by rats.
Am Ind Hyg Assoc J. 1963 Jan-Feb;24:42-6. doi: 10.1080/00028896309342922.
2
Enzymes in lung lavage fluid after inhalation exposure to silica dust.
Environ Res. 1984 Apr;33(2):307-11. doi: 10.1016/0013-9351(84)90028-8.
3
Pulmonary macrophage phagocytosis and enzyme production after in vivo exposure to silica dust.
Toxicol Appl Pharmacol. 1983 Mar 30;68(1):152-9. doi: 10.1016/0041-008x(83)90364-2.
4
Bronchopulmonary humoral and cellular enhancement in experimental silicosis.
J Reticuloendothel Soc. 1981 Feb;29(2):153-61.
5
Liberation of a fibrogenic factor from human blood monocytes, ascites cells, cultured histiocytes and transformed mouse macrophages by treatment with SiO2.
Scand J Clin Lab Invest. 1980 Jun;40(4):311-8. doi: 10.3109/00365518009092649.
6
Biological effects and toxicity assessment of titanium dioxides: anatase and rutile.
Am Ind Hyg Assoc J. 1985 Feb;46(2):69-72. doi: 10.1080/15298668591394419.
7
Biological activity of titanium dioxides.
Int Arch Occup Environ Health. 1979 Apr 20;43(2):93-7. doi: 10.1007/BF00378147.
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