Department of Medicine, University of Verona, 37129 Verona, Italy.
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37129 Verona, Italy.
Nutrients. 2018 Nov 5;10(11):1689. doi: 10.3390/nu10111689.
Obesity is often accompanied by metabolic and haemodynamic disorders such as hypertension, even during childhood. Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP450) enzymes to epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), vasoactive and natriuretic metabolites that contribute to blood pressure (BP) regulation. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) omega-3 polyunsaturated fatty acids may compete with AA for CYP450-dependent bioactive lipid mediator formation. We aimed at investigating the role of AA, EPA and DHA and their CYP450-dependent metabolites in BP control and vascular function in 66 overweight/obese children. Fatty acid profile moderately correlated with the corresponding CYP450-derived metabolites but their levels did not differ between children with normal BP (NBP) and high BP (HBP), except for higher EPA-derived epoxyeicosatetraenoic acids (EEQs) and their diols in HBP group, in which also the estimated CYP450-epoxygenase activity was higher. In the HBP group, EPA inversely correlated with BP, EEQs inversely correlated both with systolic BP and carotid Intima-Media Thickness (cIMT). The DHA-derived epoxydocosapentaenoic acids (EDPs) were inversely correlated with diastolic BP. Omega-3 derived epoxymetabolites appeared beneficially associated with BP and vascular structure/function only in obese children with HBP. Further investigations are needed to clarify the role of omega-3/omega-6 epoxymetabolites in children's hemodynamics.
肥胖常伴有代谢和血液动力学紊乱，如高血压，甚至在儿童时期也是如此。花生四烯酸（AA）被细胞色素 P450（CYP450）酶代谢为环氧化物二十碳三烯酸（EETs）和 20-羟二十碳四烯酸（20-HETE），这些血管活性和利钠代谢物有助于血压（BP）调节。二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）ω-3 多不饱和脂肪酸可能与 AA 竞争 CYP450 依赖性生物活性脂质介质的形成。我们旨在研究 AA、EPA 和 DHA 及其 CYP450 依赖性代谢物在 66 名超重/肥胖儿童的 BP 控制和血管功能中的作用。脂肪酸谱与相应的 CYP450 衍生代谢物中度相关，但在正常血压（NBP）和高血压（HBP）儿童之间，其水平没有差异，除了 HBP 组中 EPA 衍生的环氧二十碳四烯酸（EEQs）及其二醇水平较高，且 CYP450-加氧酶活性也较高。在 HBP 组中，EPA 与 BP 呈负相关，EEQs 与收缩压和颈动脉内膜-中层厚度（cIMT）均呈负相关。DHA 衍生的环氧二十二碳五烯酸（EDPs）与舒张压呈负相关。只有在患有 HBP 的肥胖儿童中，ω-3 衍生的环氧代谢物似乎与 BP 和血管结构/功能呈有益相关。需要进一步研究以阐明 ω-3/ω-6 环氧代谢物在儿童血液动力学中的作用。
