Hauser K F, McLaughlin P J, Zagon I S
Brain Res. 1987 Jul 21;416(1):157-61. doi: 10.1016/0006-8993(87)91509-5.
Continuous blockade of endogenous opioid-opioid receptor interaction by opioid antagonists from birth to day 10 increased neuronal maturation in the rat brain. The lengths of oblique dendrites of pyramidal cells in the cerebral cortex and basilar dendrites of the hippocampus were increased from controls by 136 and 51%, respectively, whereas the concentrations of spines in these cells were increased 183 and 69%, respectively. Total dendritic length of spiny branches of cerebellar Purkinje neurons was 65% greater than controls, and spine concentration of granule cells in the dentate gyrus was increased by 76%. Thus, endogenous opioids exert a remarkable influence on the timetable and magnitude of dendritic elaboration and spine formation, and serve as an important trophic influence in the regulation of neuro-ontogeny.
从出生到第10天，用阿片类拮抗剂持续阻断内源性阿片-阿片受体相互作用可促进大鼠大脑神经元成熟。大脑皮质锥体细胞的斜向树突长度和海马基底树突长度分别比对照组增加了136%和51%，而这些细胞中的棘突浓度分别增加了183%和69%。小脑浦肯野神经元有棘分支的总树突长度比对照组大65%，齿状回颗粒细胞的棘突浓度增加了76%。因此，内源性阿片类物质对树突细化和棘突形成的时间表及程度有显著影响，并在神经个体发育的调节中作为一种重要的营养影响因素。
