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肿瘤学中的图像引导骨愈合

Image-Guided Bone Consolidation in Oncology.

作者信息

Buy Xavier, Catena Vittorio, Roubaud Guilhem, Crombe Amandine, Kind Michèle, Palussiere Jean

机构信息

Department of Radiology, Institut Bergonie, Bordeaux, France.

Department of Medical Oncology, Institut Bergonie, Bordeaux, France.

出版信息

Semin Intervent Radiol. 2018 Oct;35(4):221-228. doi: 10.1055/s-0038-1669468. Epub 2018 Nov 5.

Abstract

Occurrence of bone metastases is a common event in oncology. Bone metastases are associated with pain, functional impairment, and fractures, particularly when weight-bearing bones are involved. Management of bone metastases has been improved by the development of various interventional radiology consolidation techniques. Cementoplasty is based on injection of acrylic cement into a weakened bone to reinforce it and to control pain. This minimally invasive technique has proven its efficacy for flat bone submitted to compression forces. However, resistance to torsion forces is limited and, thus, treatment of long bones should be considered with caution. In recent years, variant techniques of percutaneous bone consolidation have emerged, including expansion devices for vertebral augmentation and percutaneous screw fixation for pelvic bone and proximal femur tumors. Research projects are ongoing to develop drug-loaded cements to use them as therapeutic vectors. However, release of drugs is still poorly controlled and conventional polymethylmethacrylate cement remains the gold standard in oncology. Image-guided consolidation techniques enhance the array of treatments in bone oncology. Multidisciplinary approach is mandatory to select the best indications.

摘要

骨转移的发生在肿瘤学中是常见事件。骨转移与疼痛、功能障碍和骨折相关,尤其是当负重骨受累时。各种介入放射学强化技术的发展改善了骨转移的治疗。骨水泥成形术是将丙烯酸骨水泥注入弱化骨以加固并控制疼痛。这种微创技术已证明其对承受压缩力的扁平骨有效。然而,其抗扭力有限,因此,治疗长骨时应谨慎考虑。近年来,出现了经皮骨强化的变体技术,包括用于椎体强化的扩张装置以及用于骨盆骨和股骨近端肿瘤的经皮螺钉固定。正在开展研究项目以开发载药骨水泥用作治疗载体。然而,药物释放仍难以控制,传统的聚甲基丙烯酸甲酯骨水泥仍是肿瘤学中的金标准。图像引导的强化技术增加了骨肿瘤学的治疗手段。必须采用多学科方法来选择最佳适应证。

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