血清γ-羧基凝血酶原在乙型肝炎病毒相关肝细胞癌诊断中的评价：一项荟萃分析。
Evaluation of Serum Des-Gamma-Carboxy Prothrombin for the Diagnosis of Hepatitis B Virus-Related Hepatocellular Carcinoma: A Meta-Analysis.
机构信息
Department of Traditional Chinese Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, #79 Qingchun Road, Hangzhou, Zhejiang Province, China 310003.
出版信息
Dis Markers. 2018 Oct 4;2018:8906023. doi: 10.1155/2018/8906023. eCollection 2018.
AIM
To explore the diagnostic efficacy of des-gamma-carboxy prothrombin (DCP) in hepatitis B virus- (HBV-) related hepatocellular carcinoma (HCC).
METHODS
A retrospective study of 459 cases from June 2016 to March 2018 was undertaken, and records of the DCP levels were extracted. The sensitivity, specificity, and cutoff points were calculated using SPSS 17.0 software. A systematic search in PubMed, Web of Science, and the Cochrane Central Register of Controlled Trials was performed for articles published in English from 1997 to 2017, focusing on serum DCP for HBV-related HCC. Data on sensitivity, specificity, the positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) were extracted from five studies by systematic search and one study of our own. The summary receiver operating characteristic (sROC) curve was obtained, and the area under the receiver operating characteristic (AUROC) curve was calculated.
RESULTS
The pooled sensitivity, specificity, PLR, NLR, and DOR were 0.71 (95% CI: 0.59, 0.80), 0.93 (95% CI: 0.87, 0.96), 9.5 (95% CI: 5.2, 17.5), 0.32 (95% CI: 0.22, 0.46), and 30 (95% CI: 13, 72), respectively. The AUROC curve was 0.91 (95% CI: 0.88, 0.93).
CONCLUSIONS
In the diagnosis of HBV-related hepatocellular carcinoma (HCC), DCP is an ideal marker that should be considered for surveillance purposes.
目的
探讨脱-γ-羧基凝血酶原（DCP）在乙型肝炎病毒（HBV）相关肝细胞癌（HCC）中的诊断效能。
方法
回顾性分析 2016 年 6 月至 2018 年 3 月间的 459 例病例，提取 DCP 水平记录。采用 SPSS 17.0 软件计算灵敏度、特异性和截断值。在 PubMed、Web of Science 和 Cochrane 中央对照试验注册库中以英文发表的文章进行系统检索，检索时间从 1997 年至 2017 年，重点关注 DCP 对 HBV 相关 HCC 的诊断价值。通过系统检索和我们自己的一项研究，从五项研究中提取灵敏度、特异性、阳性似然比（PLR）、阴性似然比（NLR）和诊断比值比（DOR）的数据。获得汇总受试者工作特征（sROC）曲线，并计算曲线下面积（AUROC）。
结果
汇总灵敏度、特异性、PLR、NLR 和 DOR 分别为 0.71（95%CI：0.59，0.80）、0.93（95%CI：0.87，0.96）、9.5（95%CI：5.2，17.5）、0.32（95%CI：0.22，0.46）和 30（95%CI：13，72）。AUROC 曲线为 0.91（95%CI：0.88，0.93）。
结论
在诊断 HBV 相关 HCC 时，DCP 是一种理想的标志物，可考虑用于监测目的。
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