Gil-Ibañez Blanca, Regueiro Purificacion, Llurba Elisa, Fariñas-Madrid Lorena, Garcia Angel, Diaz-Feijoo Berta
Unit of Gynecological Oncology, Institute Clinic of Gynecology, Obstetrics and Neonatology (ICGON), Hospital Clinic of Barcelona, 08036 Barcelona, Spain.
Department of Obstetrics and Gynecology, General Hospital of Hospitalet, 08906 Barcelona, Spain.
Mol Clin Oncol. 2018 Nov;9(5):519-522. doi: 10.3892/mco.2018.1717. Epub 2018 Sep 13.
Large-cell neuroendocrine carcinoma (LCNEC) is an uncommon histological subtype of cervical cancer that is associated with poor survival and its occurrence during pregnancy is particularly rare. We herein present the case of a female patient who was diagnosed with cervical LCNEC during pregnancy. The patient declined pregnancy termination and was treated with neoadjuvant chemotherapy with cisplatin and etoposide, without associated toxicity and with good fetal development. At 31.4 weeks of gestation, the fetus was delivered by caesarean section, and the patient underwent radical nerve-sparing hysterectomy with bilateral adnexectomy, along with pelvic and inframesenteric para-aortic lymphadenectomy. The patient received adjuvant chemoradiotherapy and there was no evidence of recurrence or metastasis at 38 months postoperatively. The baby has also been followed up, without any signs of neurodevelopmental disorders. To the best of our knowledge, the present report describes the first case of LCNEC with pregnancy-preserving management in the literature to date.
大细胞神经内分泌癌（LCNEC）是宫颈癌中一种罕见的组织学亚型，其与生存率低相关，且在妊娠期发生尤为罕见。我们在此报告一例在妊娠期被诊断为宫颈LCNEC的女性患者。患者拒绝终止妊娠，接受了顺铂和依托泊苷的新辅助化疗，未出现相关毒性反应，胎儿发育良好。妊娠31.4周时，通过剖宫产分娩胎儿，患者接受了保留神经的根治性子宫切除术及双侧附件切除术，同时进行了盆腔和肠系膜下主动脉旁淋巴结切除术。患者接受了辅助放化疗，术后38个月无复发或转移迹象。婴儿也进行了随访，未出现任何神经发育障碍的迹象。据我们所知，本报告描述了迄今为止文献中首例采用保留妊娠管理的LCNEC病例。
