Breast Cancer Unit, Service of Gynecology, Hospital Vall d'Hebron, Barcelona, Spain.
Breast. 2012 Jun;21(3):272-5. doi: 10.1016/j.breast.2011.10.001. Epub 2011 Oct 21.
We assessed whether pregnancy after breast cancer in patients younger than 36 years of age affects the prognosis. Of 115 women with breast cancer followed for a mean of 6 years, 18 became pregnant (median time between diagnosis and the first pregnancy 44.5 months). Voluntary interruption of pregnancy was decided by 8 (44.4%) women. Significant differences in prognostic factors between pregnant and non-pregnant women were not observed. Pregnant women showed a lower frequency of positive estrogen receptors (41%) than non-pregnant (64%) (P=0.06). At 5 years of follow-up, 100% of women in the pregnant group and 80% in the non-pregnant group were alive. The percentages of disease-free women were 94% and 64%, respectively (P=0.009). Breast cancer patients presented a high number of unwanted pregnancies. Pregnancy after breast cancer not only did not adversely affect prognosis of the neoplasm but also may have a protective effect.
我们评估了 36 岁以下乳腺癌患者的妊娠是否会影响预后。在平均随访 6 年的 115 名乳腺癌患者中，有 18 名怀孕（诊断后首次怀孕的中位数时间为 44.5 个月）。8 名（44.4%）妇女决定自愿终止妊娠。未观察到妊娠和未妊娠妇女之间的预后因素存在显著差异。怀孕组的雌激素受体阳性率（41%）低于未妊娠组（64%）（P=0.06）。5 年随访时，怀孕组 100%的妇女和未妊娠组 80%的妇女存活。无病妇女的百分比分别为 94%和 64%（P=0.009）。乳腺癌患者有大量意外怀孕。乳腺癌后的妊娠不仅没有对肿瘤的预后产生不利影响，而且可能具有保护作用。
