Okuda K, Fujimoto I, Hanai A, Urano Y
Cancer Res. 1987 Sep 15;47(18):4967-72.
A trend in the incidence of hepatocellular carcinoma (HCC) in Japan was studied from the data of the Osaka Cancer Registry (population, 8,512,351 in 1981) for the period of 1963-1983, the Vital Statistics of Japan, Ministry of Health and Welfare, and the Japan Autopsy Registry which contained 594,132 individually filed cases in the 26-year period from 1958 to 1983. Both cancer registry data and autopsy records showed a more than 2-fold increase in HCC incidence, particularly in the last 10 years or so, among males and a less pronounced increase in females. The same trend was borne out by the cancer registries of Nagasaki City and Miyagi Prefecture and the Vital Statistics. When studied with the autopsy data, it was found that the numbers of autopsies for cirrhosis without HCC and autopsies for HCC (with and without cirrhosis) were about the same in 1958-1961 and that currently (1980-1983) the latter is about 2 times the former. As one of the possible causes of increase in HCC incidence other than prolonged survival of patients with cirrhosis, chronic non-A, non-B hepatitis is discussed.
利用大阪癌症登记处（1981年人口为8512351）1963 - 1983年期间的数据、日本厚生省的生命统计数据以及日本尸检登记处（在1958年至1983年的26年期间包含594132份单独存档的病例），对日本肝细胞癌（HCC）的发病率趋势进行了研究。癌症登记数据和尸检记录均显示，男性HCC发病率增加了2倍多，尤其是在过去10年左右，而女性的增加幅度较小。长崎市和宫城县的癌症登记处以及生命统计数据也证实了这一趋势。当与尸检数据一起研究时发现，1958 - 1961年期间无HCC的肝硬化尸检数量与HCC（有或无肝硬化）的尸检数量大致相同，而目前（1980 - 1983年）后者约为前者的2倍。作为HCC发病率增加的可能原因之一，除了肝硬化患者的生存期延长外，还讨论了慢性非甲非乙型肝炎。
