Liu Wen-Juan, Wang Xiao-Dan, Wu Wei, Huang Xiao
MD, Department of Psychological Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai (200032), China.
Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Med Sci (Paris). 2018 Oct;34 Focus issue F1:113-115. doi: 10.1051/medsci/201834f119. Epub 2018 Nov 7.
To study the correlation between depression and blood cytokine levels in lung cancer patients.
92 patients with advanced lung cancer were evaluated for depression using the scoring index of depression self-rating scale. Lack of depression (n=24), mild depression (n=45), and moderate depression (n=23) were found in the cohort. Meanwhile, 40 healthy subjects were selected as the control group. The levels of IL-10, IL-6, IL-8, and TNF-α in each group were detected by sandwich enzyme-linked immunosorbent assays, and their correlation with the degree of depression was analyzed.
The levels of IL-10, IL-6, IL-8, and TNF-α were all higher than those in the control group (P<0.05). Moreover, the depression statuses of patients with lung cancer were positively correlated with IL-10, IL-6, and TNF-α levels (r = 0.705, 0.301, and 0.446, P<0.01); however, the level of IL-8 was not relevant (r=0.136, p>0.05).
Serum levels of IL-10, IL-6, and TNF-α are associated with depression scoring in patients with lung cancer.
研究肺癌患者抑郁与血液细胞因子水平之间的相关性。
采用抑郁自评量表评分指数对92例晚期肺癌患者进行抑郁评估。该队列中发现无抑郁患者（n = 24）、轻度抑郁患者（n = 45）和中度抑郁患者（n = 23）。同时，选取40名健康受试者作为对照组。采用夹心酶联免疫吸附测定法检测每组中白细胞介素-10（IL-10）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）和肿瘤坏死因子-α（TNF-α）的水平，并分析它们与抑郁程度的相关性。
IL-10、IL-6、IL-8和TNF-α的水平均高于对照组（P<0.05）。此外，肺癌患者的抑郁状态与IL-10、IL-6和TNF-α水平呈正相关（r = 0.705、0.301和0.446，P<0.01）；然而，IL-8水平无相关性（r = 0.136，P>0.05）。
肺癌患者血清IL-10、IL-6和TNF-α水平与抑郁评分相关。
