Fan Ni, Luo Yayan, Ou Yufen, He Hongbo
The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, Guangdong Province, China.
Hum Psychopharmacol. 2017 Jul;32(4). doi: 10.1002/hup.2588. Epub 2017 Jun 5.
Depressive disorder is associated with abnormal changes in cytokines levels. This study aimed to assess serum concentrations of tumor necrosis factor (TNF) α, interleukin (IL) 6, and IL-18 in depressive patients. The correlations between these three cytokine concentrations and the patients' clinical characteristics were also assessed.
Serum TNF-α, IL-6, and IL-18 concentrations were assessed using enzyme-linked immunosorbent assay from 64 depressive patients and 80 healthy control subjects. Depressive symptoms of patients were assessed using Hamilton Depression Scale-17.
Depressive patients had increased serum TNF-α and IL-6 concentrations but decreased IL-18 concentrations than controls. TNF-α and IL-6 concentrations were significantly positively associated with Hamilton Depression Scale-17 scores in depressive patients.
These findings provided additional evidence that altered TNF-α, IL-6, and IL-18 activities may contribute to the pathophysiology of depressive disorder.
抑郁症与细胞因子水平的异常变化有关。本研究旨在评估抑郁症患者血清中肿瘤坏死因子（TNF）α、白细胞介素（IL）6和IL-18的浓度。还评估了这三种细胞因子浓度与患者临床特征之间的相关性。
采用酶联免疫吸附测定法评估64例抑郁症患者和80例健康对照者血清中TNF-α、IL-6和IL-18的浓度。使用汉密尔顿抑郁量表-17评估患者的抑郁症状。
与对照组相比，抑郁症患者血清TNF-α和IL-6浓度升高，但IL-18浓度降低。抑郁症患者中，TNF-α和IL-6浓度与汉密尔顿抑郁量表-17评分显著正相关。
这些发现提供了额外的证据，表明TNF-α、IL-6和IL-18活性的改变可能有助于抑郁症的病理生理过程。
