抗原呈递对不同功能辅助性T细胞生成的影响。
The influence of antigen presentation on the generation of T-helper cells with different functions.
作者信息
Waldmann H, Pope H
出版信息
Immunology. 1977 Nov;33(5):721-5.
Abstract
Thymocytes adoptively transferred into syngeneic irradiated recipients can be primed with antigen (KLH) to generate two types of helper function termed 'specific' and 'non-specific'. Low doses of KLH given without adjuvant generate high levels of non-specific compared to 'specific' helper T cells. Large doses of KLH given in adjuvant (FCA) generate high levels of both types of helper T cell. Explantations for this observation are discussed.
摘要
将胸腺细胞过继转移到同基因受辐照受体中后，可用抗原（钥孔血蓝蛋白，KLH）进行致敏，以产生两种辅助功能，分别称为“特异性”和“非特异性”。与“特异性”辅助性T细胞相比，无佐剂情况下给予低剂量KLH可产生高水平的非特异性辅助性T细胞。在佐剂（弗氏完全佐剂，FCA）中给予大剂量KLH可产生高水平的两种辅助性T细胞。文中讨论了对此观察结果的解释。
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