Beijing Advance Innovation center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing, China.
Beijing Engineering and Technology Research Center of Food Additives, School of Food and Chemical Technology, Beijing Technology and Business University, Beijing, China.
Chem Biol Drug Des. 2019 Apr;93(4):387-418. doi: 10.1111/cbdd.13437. Epub 2019 Jan 24.
Hyperuricemia (HUA), a disease due to an elevation of body uric acid level and responsible for various diseases such as gout, cardiovascular disorders, and renal failure, is a major ground debate for the medical science these days. Considering the risk factors linked with allopathic drugs for the treatment of this disease, the debate has now become a special issue. Previously, we critically discussed the role of dietary polyphenols in the treatment of HUA. Besides dietary food plants, many researchers figure out the tremendous effects of medicinal plants-derived phytochemicals against HUA. Keeping in mind all these aspects, we reviewed all possible managerial studies related to HUA through medicinal plants (isolated compounds). In the current review article, we comprehensively discussed various bioactive compounds, chemical structures, and structure-activity relationship with responsible key enzyme xanthine oxidase.
高尿酸血症（HUA）是一种由于血尿酸水平升高而引起的疾病，可导致痛风、心血管疾病和肾衰竭等多种疾病，是当前医学领域的一个主要研究热点。鉴于治疗这种疾病的西药存在各种风险因素，该研究热点现在已成为一个特殊问题。此前，我们曾深入探讨了膳食多酚在治疗 HUA 中的作用。除了膳食植物性食物外，许多研究人员还发现了植物源性植物化学物质在治疗 HUA 方面的巨大作用。基于这些方面，我们通过药用植物（分离化合物）对与 HUA 相关的所有可能的管理研究进行了综述。在当前的综述文章中，我们全面讨论了各种生物活性化合物、化学结构以及与负责关键酶黄嘌呤氧化酶的结构-活性关系。
