托法替布治疗坏疽性脓皮病。
Tofacitinib for the Treatment of Pyoderma Gangrenosum.
机构信息
Multidisciplinary Center for Inflammatory Bowel Disease, University of North Carolina, Chapel Hill, North Carolina; Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina.
Division of Gastroenterology and Hepatology, University Hospital and University of Zurich, Zurich, Switzerland.
出版信息
Clin Gastroenterol Hepatol. 2019 Apr;17(5):991-993. doi: 10.1016/j.cgh.2018.10.047. Epub 2018 Nov 4.
Pyoderma gangrenosum (PG) is a difficult-to-treat inflammatory skin condition that affects inflammatory bowel disease (IBD) patients. There is no standardized approach for PG treatment. We report the results of 3 patients with Crohn's disease (CD) and refractory PG who had failed several therapies with biologics and were started on tofacitinib for severe inflammatory arthritis with resolution of their PG.
坏疽性脓皮病（PG）是一种难以治疗的炎症性皮肤病，影响炎症性肠病（IBD）患者。PG 的治疗方法没有标准化。我们报告了 3 例克罗恩病（CD）和难治性 PG 患者的结果，他们在生物制剂治疗失败后，因严重炎症性关节炎开始使用托法替尼，PG 得到缓解。
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