在焦虑症患者接受地西泮治疗期间，血小板膜上的外周苯二氮䓬结合位点会增加。
Peripheral benzodiazepine binding sites on platelet membranes are increased during diazepam treatment of anxious patients.
作者信息
Weizman R, Tanne Z, Granek M, Karp L, Golomb M, Tyano S, Gavish M
出版信息
Eur J Pharmacol. 1987 Jun 19;138(2):289-92. doi: 10.1016/0014-2999(87)90447-x.
PMID:3040435
Abstract
Reduced (24%) [3H]PK 11195 binding capacity to platelet membranes was observed in anxious patients in comparison to age- and sex-matched normal controls. Four weeks of diazepam treatment induced elevation (69%) in the maximal number of binding sites, and 1 week of drug withdrawal resulted in a slight decrease (16%) in 'peripheral' benzodiazepine binding sites as compared to their level during treatment.
摘要
与年龄和性别匹配的正常对照组相比，焦虑症患者血小板膜上[3H]PK 11195的结合能力降低了24%。地西泮治疗四周后，结合位点的最大数量增加了69%，停药一周后，“外周”苯二氮䓬结合位点相较于治疗期间略有下降（16%）。
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