人类血小板外周苯二氮䓬受体的年龄相关变化。
Age-related changes in peripheral benzodiazepine receptors of human platelets.
作者信息
Marazziti D, Pancioli-Guadagnucci M L, Rotondo A, Giannaccini G, Martini C, Lucacchini A, Cassano G B
机构信息
Institute of Psychiatry, University of Pisa, Italy.
出版信息
J Psychiatry Neurosci. 1994 Mar;19(2):136-9.
Abstract
Using 3H-PK 11195 as radioligand, the number and affinity of peripheral benzodiazepine receptors in platelets of 15 elderly healthy subjects were compared to those of 15 young subjects. The results showed that the dissociation constant (Kd) was significantly higher in the elderly than in the young subjects, while the density of binding sites did not differ. These findings suggest that the age-related changes in peripheral benzodiazepine receptors may be coupled with secondary changes in their hypothesized functions.
摘要
以3H-PK 11195作为放射性配体，比较了15名老年健康受试者与15名年轻受试者血小板中苯二氮䓬外周受体的数量和亲和力。结果显示，老年受试者的解离常数（Kd）显著高于年轻受试者，而结合位点密度无差异。这些发现表明，苯二氮䓬外周受体与年龄相关的变化可能与其假定功能的继发性变化有关。
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