利用电泳修饰的惯性效应在具有对称半圆障碍物阵列的直通道中实现可调谐粒子聚焦。

Tunable Particle Focusing in a Straight Channel with Symmetric Semicircle Obstacle Arrays Using Electrophoresis-Modified Inertial Effects.

作者信息

Yuan Dan, Pan Chao, Zhang Jun, Yan Sheng, Zhao Qianbin, Alici Gursel, Li Weihua

机构信息

School of Mechanical, Materials and Mechatronic Engineering, University of Wollongong, Wollongong, NSW 2522, Australia.

School of Mechanical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.

出版信息

Micromachines (Basel). 2016 Nov 1;7(11):195. doi: 10.3390/mi7110195.

DOI:10.3390/mi7110195

PMID:30404368

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6189854/

Abstract

In this work, a novel microfluidic platform for tunable particle focusing in a straight channel with symmetric semicircle obstacle arrays using electrophoresis (EP)-modified inertial effects was presented. By exerting an EP force on the charged microparticles, a relative velocity gap between microspheres and fluid in a straight channel with symmetric semicircle obstacle arrays was implemented. The relative velocity and fluid shear will induce shear-slip lift force (Saffman lift force) perpendicular to the mainstream direction. Therefore, the focusing pattern can be altered using the electrophoresis-induced Saffman force. The effects of electric field direction, flow rate, electric field magnitude, and particle size were also studied. This demonstrates the possibility of adjusting the particle inertial focusing pattern in a straight channel with with symmetric semicircle obstacle arrays using electrophoresis. Manipulation of the lateral migration of focusing streaks increases controllability in applications such as blood cell filtration and the separation of cells by size.

摘要

在这项工作中，提出了一种新型微流控平台，该平台利用电泳（EP）修饰的惯性效应，在具有对称半圆障碍物阵列的直通道中实现可调谐粒子聚焦。通过对带电微粒施加电场力，在具有对称半圆障碍物阵列的直通道中实现了微球与流体之间的相对速度差。相对速度和流体剪切力将产生垂直于主流方向的剪切滑移升力（萨夫曼升力）。因此，可利用电泳诱导的萨夫曼力改变聚焦模式。还研究了电场方向、流速、电场强度和颗粒大小的影响。这证明了利用电泳在具有对称半圆障碍物阵列的直通道中调节粒子惯性聚焦模式的可能性。对聚焦条纹横向迁移的操控提高了诸如血细胞过滤和按大小分离细胞等应用中的可控性。