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[噬菌体φ80引起的溶原性转变。III. 转变基因的定位及该现象的进一步特征分析]

[Lysogenic conversion caused by phage phi 80. III. The mapping of the conversion gene and additional characterization of the phenomenon].

作者信息

Kozyrev D P, Rybchin V N

出版信息

Genetika. 1987 May;23(5):793-801.

PMID:3040526
Abstract

The cor gene specifies lysogenic conversion caused by the lambdoid phage phi 80. The cor gene product inhibits tonA function in infected and lysogenic cells. The cells harboring pBR322 plasmid with the cloned cor gene of phi 80 became resistant to the phages T1 and phi 80 (TonA phenotype). The cor gene was mapped between 24 and 13 genes on the phi 80 phage genetic map. It is not essential for phage lytic growth. Its presence in lysogens leads up to accumulation of tonA mutants in a cell population.

摘要

cor基因决定了由类λ噬菌体φ80引起的溶原性转变。cor基因产物在受感染和溶原性细胞中抑制tonA功能。携带含有φ80克隆cor基因的pBR322质粒的细胞对噬菌体T1和φ80产生抗性(TonA表型)。cor基因定位在φ80噬菌体遗传图谱上的24和13基因之间。它对噬菌体裂解生长不是必需的。它在溶原菌中的存在导致细胞群体中tonA突变体的积累。

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