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开发一种促进骨骼健康的人工手指状膝关节加载装置。

Development of an Artificial Finger-Like Knee Loading Device to Promote Bone Health.

作者信息

Korupolu Sandeep, Chien Stanley, Yokota Hiroki, Anwar Sohel

机构信息

Department of Mechanical Engineering, Indiana University Purdue University Indianapolis (IUPUI), Indianapolis, IN, USA.

Department of Electrical and Computer Engineering, Indiana University Purdue University Indianapolis (IUPUI), Indianapolis, IN, USA.

出版信息

J Biomed Sci Eng. 2017 Nov;10(11):550-561. doi: 10.4236/jbise.2017.1011041.

Abstract

This study presents the development of an innovative artificial finger-like device that provides position specific mechanical loads at the end of the long bone and induces mechanotransduction in bone. Bone cells such as osteoblasts are the mechanosensitive cells that regulate bone remodelling. When they receive gentle, periodic mechanical loads, new bone formation is promoted. The proposed device is an under-actuated multi-fingered artificial hand with 4 fingers, each having two phalanges. These fingers are connected by mechanical linkages and operated by a worm gearing mechanism. With the help of 3D printing technology, a prototype device was built mostly using plastic materials. The experimental validation results show that the device is capable of generating necessary forces at the desired frequencies, which are suitable for the stimulation of bone cells and the promotion of bone formation. It is recommended that the device be tested in a clinical study for confirming its safety and efficacy with patients.

摘要

本研究展示了一种创新的人工手指状装置的研发,该装置可在长骨末端提供特定位置的机械负荷并诱导骨内的机械转导。成骨细胞等骨细胞是调节骨重塑的机械敏感细胞。当它们受到轻柔、周期性的机械负荷时,会促进新骨形成。所提出的装置是一种欠驱动的多指人工手,有4个手指,每个手指有两个指骨。这些手指通过机械连杆连接,并由蜗轮传动机构操作。借助3D打印技术,主要使用塑料材料制造了一个原型装置。实验验证结果表明,该装置能够在所需频率下产生必要的力,这些力适用于刺激骨细胞和促进骨形成。建议在临床研究中对该装置进行测试,以确认其对患者的安全性和有效性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dab/6217823/42e0384fbda9/nihms967528f1.jpg

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本文引用的文献

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Osteoinduction, osteoconduction and osseointegration.骨诱导、骨传导和骨结合。
Eur Spine J. 2001 Oct;10 Suppl 2(Suppl 2):S96-101. doi: 10.1007/s005860100282.
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Bone deformation recorded in vivo from strain gauges attached to the human tibial shaft.
Acta Orthop Scand. 1975 May;46(2):256-68. doi: 10.3109/17453677508989216.

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