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首例由……引起的胸膜脓胸:文献综述

First Case of Pleural Empyema Caused by : Review of the Literature.

作者信息

Lal Amos, Akhtar Jamal, Ullah Ashfaq, Abraham George M

机构信息

Department of Medicine, Saint Vincent Hospital, 123 Summer Street, Worcester, MA 01608, USA.

Department of Medicine, Division of Pulmonology and Critical Care Medicine, Saint Vincent Hospital, 123 Summer Street, Worcester, MA 01608, USA.

出版信息

Case Rep Infect Dis. 2018 Oct 11;2018:7831284. doi: 10.1155/2018/7831284. eCollection 2018.

Abstract

is a coagulase-negative organism, mainly an animal pathogen. Reports of human infection have been infrequent, mainly in patients with repeated animal contact. We report the first case of pleural empyema in an elderly woman. tends to cause more severe infection because of a biofilm layer which helps in adherence and colonization of smooth surfaces, especially prosthetic devices, shunts, and catheters. The challenging problem even after CoNS isolation and identification is the assessment of their clinical relevance. Major factors that inhibit the penetration of antibiotics is the large-sized effusions/empyema, thickness of pleura, and the nature of antibiotic itself. Source control for septic patients remains the cornerstone of treatment along with optimal antimicrobial coverage. , a coagulase-negative staphylococcus, is emerging as an important cause of virulent infections with high mortality in humans. Given its propensity for multidrug resistance, including vancomycin, there is an imperative for early and accurate identification of the isolate. Despite aggressive treatment, the patient succumbed to her illness.

摘要

是一种凝固酶阴性菌,主要是动物病原体。人类感染的报告很少,主要发生在反复接触动物的患者中。我们报告了一例老年女性胸膜脓胸的首例病例。由于生物膜层有助于在光滑表面(特别是假体装置、分流器和导管)上附着和定植,往往会导致更严重的感染。即使在分离和鉴定凝固酶阴性葡萄球菌之后,具有挑战性的问题是评估它们的临床相关性。抑制抗生素渗透的主要因素是大量胸腔积液/脓胸、胸膜厚度以及抗生素本身的性质。对于脓毒症患者,源头控制与最佳抗菌覆盖仍然是治疗的基石。作为一种凝固酶阴性葡萄球菌,正在成为人类中具有高死亡率的毒性感染的重要原因。鉴于其对包括万古霉素在内的多种药物耐药的倾向,迫切需要早期准确鉴定分离株。尽管进行了积极治疗,患者仍因病死亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc7/6201379/7e4eb85bd023/CRIID2018-7831284.001.jpg

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