Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia.
Institute of Biology and Ecology, Faculty of Science, University of Kragujevac, Radoja Domanovica 12, 34000 Kragujevac, Serbia.
Anal Cell Pathol (Amst). 2018 Oct 14;2018:6192187. doi: 10.1155/2018/6192187. eCollection 2018.
Recently, epidermal growth factor receptor (EGFR) was a key molecule in investigation of lung cancer, and it was a target for a new therapeutic strategy, based on molecular analyses. In this review, we have summarized some issues considering the role of EGFR in lung cancer, its coding gene, and its promoter gene polymorphisms (SNPs) -216G/T and -191C/A in non-small-cell lung cancer (NSCLC). The position of the SNPs indicates their significant role in EGFR regulation. The accumulation of knowledge regarding SNPs lately suggests their significant and important role in the onset of carcinogenesis, the prediction of the onset of metastases, the response to therapy with TKI inhibitors, and the onset of toxic effects of the applied therapy. Based on this, we suggest further studies of the relationship of clinical significance to SNPs in patients with lung tumors.
最近，表皮生长因子受体 (EGFR) 是肺癌研究中的关键分子，也是基于分子分析的新治疗策略的靶点。在这篇综述中，我们总结了一些关于 EGFR 在非小细胞肺癌 (NSCLC) 中的作用、其编码基因及其启动子基因多态性 (SNP)-216G/T 和 -191C/A 的问题。SNP 的位置表明它们在 EGFR 调节中的重要作用。最近关于 SNP 的知识积累表明，它们在肿瘤发生、转移发生的预测、TKI 抑制剂治疗反应以及应用治疗毒性作用的发生方面具有重要作用。基于此，我们建议进一步研究与肺肿瘤患者临床意义相关的 SNP 关系。
