Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Neural Regeneration and Repair, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Mol Neurobiol. 2019 Jul;56(7):4880-4893. doi: 10.1007/s12035-018-1403-3. Epub 2018 Nov 8.
Ferroptosis is a recently identified, iron-regulated, non-apoptotic form of cell death. It is characterized by cellular accumulation of lipid reactive oxygen species that ultimately leads to oxidative stress and cell death. Although first identified in cancer cells, ferroptosis has been shown to have significant implications in several neurologic diseases, such as ischemic and hemorrhagic stroke, Alzheimer's disease, and Parkinson's disease. This review summarizes current research on ferroptosis, its underlying mechanisms, and its role in the progression of different neurologic diseases. Understanding the role of ferroptosis could provide valuable information regarding treatment and prevention of these devastating diseases.
铁死亡是一种新近发现的、受铁调控的、非细胞凋亡性的细胞死亡形式。其特征是细胞内脂质活性氧的积累，最终导致氧化应激和细胞死亡。虽然最初在癌细胞中被发现，但铁死亡在几种神经疾病中具有重要意义，如缺血性和出血性中风、阿尔茨海默病和帕金森病。本综述总结了铁死亡的最新研究进展、其潜在机制以及在不同神经疾病进展中的作用。了解铁死亡的作用可能为这些毁灭性疾病的治疗和预防提供有价值的信息。
