铁死亡及其在多种脑部疾病中的作用。
Ferroptosis and Its Role in Diverse Brain Diseases.
机构信息
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Neural Regeneration and Repair, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
出版信息
Mol Neurobiol. 2019 Jul;56(7):4880-4893. doi: 10.1007/s12035-018-1403-3. Epub 2018 Nov 8.
Abstract
Ferroptosis is a recently identified, iron-regulated, non-apoptotic form of cell death. It is characterized by cellular accumulation of lipid reactive oxygen species that ultimately leads to oxidative stress and cell death. Although first identified in cancer cells, ferroptosis has been shown to have significant implications in several neurologic diseases, such as ischemic and hemorrhagic stroke, Alzheimer's disease, and Parkinson's disease. This review summarizes current research on ferroptosis, its underlying mechanisms, and its role in the progression of different neurologic diseases. Understanding the role of ferroptosis could provide valuable information regarding treatment and prevention of these devastating diseases.
摘要
铁死亡是一种新近发现的、受铁调控的、非细胞凋亡性的细胞死亡形式。其特征是细胞内脂质活性氧的积累，最终导致氧化应激和细胞死亡。虽然最初在癌细胞中被发现，但铁死亡在几种神经疾病中具有重要意义，如缺血性和出血性中风、阿尔茨海默病和帕金森病。本综述总结了铁死亡的最新研究进展、其潜在机制以及在不同神经疾病进展中的作用。了解铁死亡的作用可能为这些毁灭性疾病的治疗和预防提供有价值的信息。
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本文引用的文献
1
Glutathione peroxidase 4 participates in secondary brain injury through mediating ferroptosis in a rat model of intracerebral hemorrhage.
Brain Res. 2018 Dec 15;1701:112-125. doi: 10.1016/j.brainres.2018.09.012. Epub 2018 Sep 8.
2
Circadian control of BDNF-mediated Nrf2 activation in astrocytes protects dopaminergic neurons from ferroptosis.
Free Radic Biol Med. 2019 Mar;133:169-178. doi: 10.1016/j.freeradbiomed.2018.09.002. Epub 2018 Sep 4.
3
Ultrastructural Characteristics of Neuronal Death and White Matter Injury in Mouse Brain Tissues After Intracerebral Hemorrhage: Coexistence of Ferroptosis, Autophagy, and Necrosis.
Front Neurol. 2018 Jul 17;9:581. doi: 10.3389/fneur.2018.00581. eCollection 2018.
4
AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System X Activity.
Curr Biol. 2018 Aug 6;28(15):2388-2399.e5. doi: 10.1016/j.cub.2018.05.094. Epub 2018 Jul 26.
5
Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration.
Front Neurosci. 2018 Jul 10;12:466. doi: 10.3389/fnins.2018.00466. eCollection 2018.
6
miR-9 regulates ferroptosis by targeting glutamic-oxaloacetic transaminase GOT1 in melanoma.
Mol Carcinog. 2018 Nov;57(11):1566-1576. doi: 10.1002/mc.22878. Epub 2018 Aug 14.
7
Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma.
J Clin Invest. 2018 Aug 1;128(8):3341-3355. doi: 10.1172/JCI99032. Epub 2018 Jun 25.
8
Oxytosis/Ferroptosis-(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System.
Front Neurosci. 2018 Apr 20;12:214. doi: 10.3389/fnins.2018.00214. eCollection 2018.
9
Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis.
ACS Cent Sci. 2018 Mar 28;4(3):387-396. doi: 10.1021/acscentsci.7b00589. Epub 2018 Feb 7.
10
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