Department of Biotechnology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research-Raebareli, Lucknow, India.
J Biochem Mol Toxicol. 2021 Aug;35(8):e22830. doi: 10.1002/jbt.22830. Epub 2021 May 28.
Ferroptosis is a newly identified regulated form of cell death, which is thought to play a major role in neurodegenerative diseases. In this review, we discuss recent studies elucidating the molecular mechanisms involved in the regulation and execution of ferroptotic cell death and also its role in the brain. Ferroptosis is regulated mainly via iron homeostasis, glutathione metabolism, and lipid peroxidation. Ferroptotic cell death and pro-ferroptotic factors are correlated with the etiopathogenesis of Parkinson's disease (PD) and Alzheimer's disease (AD). Ferroptosis and etiological factors act synergistically in PD and AD pathogenesis. Furthermore, several preclinical and clinical studies targeting ferroptosis in PD and AD have also shown positive results. Evidence of ferroptosis in the brain thus gives new insights into understanding neurodegenerative diseases. Ferroptosis studies in the brain are still in their infancy, but the existing pieces of evidence suggest a strong correlation between ferroptotic cell death and neurodegenerative diseases. Thus, ferroptosis might be a promising target for treating neurodegenerative diseases.
铁死亡是一种新发现的细胞死亡形式，被认为在神经退行性疾病中起主要作用。在这篇综述中，我们讨论了最近阐明铁死亡调控和执行的分子机制的研究，以及其在大脑中的作用。铁死亡主要通过铁稳态、谷胱甘肽代谢和脂质过氧化来调节。铁死亡和促铁死亡因素与帕金森病 (PD) 和阿尔茨海默病 (AD) 的发病机制有关。铁死亡和病因因素在 PD 和 AD 的发病机制中协同作用。此外，针对 PD 和 AD 中铁死亡的几项临床前和临床研究也取得了积极的结果。大脑中的铁死亡证据为理解神经退行性疾病提供了新的见解。大脑中的铁死亡研究仍处于起步阶段，但现有的证据表明铁死亡细胞死亡与神经退行性疾病之间存在很强的相关性。因此，铁死亡可能是治疗神经退行性疾病的一个有前途的靶点。
