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药物基因组学研究出版物的基本特征。

Essential Characteristics of Pharmacogenomics Study Publications.

机构信息

Department of Biomedical Data Sciences, Stanford University, Stanford, California, USA.

Translational Software, Bellevue, Washington, USA.

出版信息

Clin Pharmacol Ther. 2019 Jan;105(1):86-91. doi: 10.1002/cpt.1279.

DOI:10.1002/cpt.1279
PMID:30406943
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6449845/
Abstract

Pharmacogenomics (PGx) can be seen as a model for biomedical studies: it includes all disease areas of interest and spans in vitro studies to clinical trials, while focusing on the relationships between genes and drugs and the resulting phenotypes. This review will examine different characteristics of PGx study publications and provide examples of excellence in framing PGx questions and reporting their resulting data in a way that maximizes the knowledge that can be built on them.

摘要

药物基因组学(PGx)可以被视为生物医学研究的一个范例:它涵盖了所有感兴趣的疾病领域,并跨越了从体外研究到临床试验的范围,同时专注于基因与药物之间的关系以及由此产生的表型。本文将探讨 PGx 研究出版物的不同特点,并提供在构建 PGx 问题和报告相关数据方面的优秀范例,以最大化可从这些研究中获得的知识。

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1
Essential Characteristics of Pharmacogenomics Study Publications.药物基因组学研究出版物的基本特征。
Clin Pharmacol Ther. 2019 Jan;105(1):86-91. doi: 10.1002/cpt.1279.
2
Pharmacogenomics and individualized medicine: translating science into practice.药物基因组学与个体化医学:将科学转化为实践。
Clin Pharmacol Ther. 2012 Oct;92(4):467-75. doi: 10.1038/clpt.2012.120. Epub 2012 Sep 5.
3
Pharmacogenomics--how close/far are we to practising individualized medicine for children?药物基因组学——我们距离为儿童实施个性化医疗还有多远/近?
Br J Clin Pharmacol. 2015 Mar;79(3):419-28. doi: 10.1111/bcp.12338.
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Using text to build semantic networks for pharmacogenomics.利用文本构建药物基因组学的语义网络。
J Biomed Inform. 2010 Dec;43(6):1009-19. doi: 10.1016/j.jbi.2010.08.005. Epub 2010 Aug 17.
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Pharmacogenetics in psychiatry: translating research into clinical practice.精神病学中的药物遗传学:将研究转化为临床实践。
Mol Psychiatry. 2012 Jul;17(8):760-9. doi: 10.1038/mp.2011.146. Epub 2011 Nov 15.
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Collaborative Counseling Considerations for Pharmacogenomic Tests.药物基因组学检测的协作咨询注意事项。
Pharmacotherapy. 2017 Sep;37(9):990-999. doi: 10.1002/phar.1980. Epub 2017 Aug 7.
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Pharmacogenetics-based therapeutic recommendations--ready for clinical practice?基于药物遗传学的治疗建议——准备好应用于临床实践了吗?
Nat Rev Drug Discov. 2005 Aug;4(8):639-47. doi: 10.1038/nrd1801.
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Systematic identification of pharmacogenomics information from clinical trials.从临床试验中系统地识别药物基因组学信息。
J Biomed Inform. 2012 Oct;45(5):870-8. doi: 10.1016/j.jbi.2012.04.005. Epub 2012 Apr 24.
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10
[Translational approach for pharmacogenomics and personalized medicine].药物基因组学与个性化医疗的转化方法
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BMC Anesthesiol. 2024 Nov 15;24(1):416. doi: 10.1186/s12871-024-02797-y.
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Appraisal and development of evidence-based clinical decision support to enable perioperative pharmacogenomic application.评估和开发基于证据的临床决策支持,以实现围手术期药物基因组学的应用。
Pharmacogenomics J. 2021 Dec;21(6):691-711. doi: 10.1038/s41397-021-00248-2. Epub 2021 Aug 10.
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Guided Cancer Therapy: Review of the Evidence and Considerations for Clinical Implementation.引导式癌症治疗:临床实施的证据综述与考量
Cancers (Basel). 2021 Mar 29;13(7):1566. doi: 10.3390/cancers13071566.
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STrengthening the Reporting Of Pharmacogenetic Studies: Development of the STROPS guideline.加强遗传药理学研究报告:STROPS 指南的制定。
PLoS Med. 2020 Sep 21;17(9):e1003344. doi: 10.1371/journal.pmed.1003344. eCollection 2020 Sep.

本文引用的文献

1
Standardization can accelerate the adoption of pharmacogenomics: current status and the path forward.标准化可加速药物基因组学的应用:现状与未来之路
Pharmacogenomics. 2018 Jul 1;19(10):847-860. doi: 10.2217/pgs-2018-0028. Epub 2018 Jun 19.
2
When will clinical trials finally reflect diversity?临床试验最终何时才能反映出多样性?
Nature. 2018 May;557(7704):157-159. doi: 10.1038/d41586-018-05049-5.
3
Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC).采用药效学和临床终点的氯吡格雷疗效的全基因组和候选基因方法——国际氯吡格雷药物基因组学联合会(ICPC)的原理和设计。
Am Heart J. 2018 Apr;198:152-159. doi: 10.1016/j.ahj.2017.12.010. Epub 2017 Dec 17.
4
Genetic Variants Influencing Plasma Renin Activity in Hypertensive Patients From the PEAR Study (Pharmacogenomic Evaluation of Antihypertensive Responses).PEAR 研究(抗高血压反应的药物基因组学评估)中影响高血压患者血浆肾素活性的遗传变异。
Circ Genom Precis Med. 2018 Apr;11(4):e001854. doi: 10.1161/CIRCGEN.117.001854.
5
Individualization of Irinotecan Treatment: A Review of Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics.个体化伊立替康治疗:药代动力学、药效学和药物遗传学综述。
Clin Pharmacokinet. 2018 Oct;57(10):1229-1254. doi: 10.1007/s40262-018-0644-7.
6
Whole-Genome Sequencing of Pharmacogenetic Drug Response in Racially Diverse Children with Asthma.种族多样化哮喘儿童药物反应的全基因组测序。
Am J Respir Crit Care Med. 2018 Jun 15;197(12):1552-1564. doi: 10.1164/rccm.201712-2529OC.
7
Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects.临床实施药物基因组学的研究方向:美国计划和项目概览。
Clin Pharmacol Ther. 2018 May;103(5):778-786. doi: 10.1002/cpt.1048. Epub 2018 Mar 30.
8
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy.临床药物遗传学实施联盟(CPIC)关于 CYP2D6 和他莫昔芬治疗的指南。
Clin Pharmacol Ther. 2018 May;103(5):770-777. doi: 10.1002/cpt.1007. Epub 2018 Jan 31.
9
The Pharmacogene Variation (PharmVar) Consortium: Incorporation of the Human Cytochrome P450 (CYP) Allele Nomenclature Database.药物基因变异(PharmVar)联盟:纳入人类细胞色素 P450(CYP)等位基因命名数据库。
Clin Pharmacol Ther. 2018 Mar;103(3):399-401. doi: 10.1002/cpt.910. Epub 2017 Nov 14.
10
Comparison of the Guidelines of the Clinical Pharmacogenetics Implementation Consortium and the Dutch Pharmacogenetics Working Group.临床药物遗传学实施联合会指南与荷兰药物遗传学工作组指南的比较。
Clin Pharmacol Ther. 2018 Apr;103(4):599-618. doi: 10.1002/cpt.762. Epub 2017 Oct 10.