From the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.
Arch Pathol Lab Med. 2019 Jan;143(1):65-74. doi: 10.5858/arpa.2018-0234-RA. Epub 2018 Nov 8.
CONTEXT.—: Gestational trophoblastic tumors include 3 distinct entities: gestational choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor. Accurate diagnosis is important for clinical management of the patient.
OBJECTIVE.—: To review clinical features and pathologic diagnosis of gestational trophoblastic tumors.
DATA SOURCES.—: Literature and personal experience are the sources for this study.
CONCLUSIONS.—: Trophoblastic tumors are rare encounters in modern medicine, as a result of clinical practice of molar surveillance programs and early chemotherapeutic intervention for persistent gestational trophoblastic neoplasia. Diagnostic recognition of these tumors requires a high index of suspicion, awareness of their histologic characteristics, and appropriate application of immunohistochemical and molecular biomarkers. Recent attention has been given to a few precursor lesions of gestational trophoblastic tumors, including early/in situ choriocarcinoma and atypical placental site nodule.
妊娠滋养细胞肿瘤包括 3 种不同的实体：妊娠绒癌、胎盘部位滋养细胞肿瘤和上皮样滋养细胞肿瘤。准确的诊断对于患者的临床管理非常重要。
回顾妊娠滋养细胞肿瘤的临床特征和病理诊断。
本研究的资料来源于文献和个人经验。
滋养细胞肿瘤在现代医学中很少见，这是由于实施了葡萄胎监测方案以及对持续性妊娠滋养细胞肿瘤进行早期化疗干预的临床实践。这些肿瘤的诊断识别需要高度怀疑、对其组织学特征的认识，以及适当应用免疫组织化学和分子生物标志物。最近，人们对一些妊娠滋养细胞肿瘤的前体病变给予了关注，包括早期/原位绒癌和不典型胎盘部位结节。
