Pazarlı Ahmet Cemal, Köseoğlu Handan İnönü, Kutlutürk Faruk, Gökçe Erkan
Department of Pulmonary Diseases, Gaziopsmanpaşa University School of Medicine, Tokat, Turkey.
Department of Internal Medicine, Gaziosmanpaşa University School of Medicine, Tokat, Turkey.
Turk Thorac J. 2017 Nov 29;20(2):157-159. doi: 10.5152/TurkThoracJ.2017.17003. Print 2019 Apr.
Acromegaly is usually characterized by the excessive secretion of growth hormone (GH) after the closure of epiphyseal plaques, resulting from functional pituitary adenomas. The most common manifestations of acromegaly are acral and soft tissue overgrowth, diabetes mellitus, hypertension, and heart and respiratory failure. In patients, obstruction of the upper airway may develop due to enlargement of the tongue and thickening of the tissues of the larynx; consequently, obstructive sleep apnea syndrome (OSAS) occurs commonly in acromegaly. Previous studies have shown an association between acromegaly and central sleep apnea syndrome (CSAS). Some of these described patients described showed that an elevation in the GH level may cause a defect in the respiratory drive. Most systemic diseases seen in acromegaly require effective treatment. We believe that it is necessary to perform effective treatments by examining respiratory disorders in sleep.
肢端肥大症通常的特征是在骨骺板闭合后生长激素（GH）分泌过多，这是由功能性垂体腺瘤引起的。肢端肥大症最常见的表现是手足和软组织过度生长、糖尿病、高血压以及心脏和呼吸衰竭。在患者中，由于舌头增大和喉部组织增厚，可能会出现上呼吸道阻塞；因此，阻塞性睡眠呼吸暂停综合征（OSAS）在肢端肥大症患者中很常见。先前的研究表明肢端肥大症与中枢性睡眠呼吸暂停综合征（CSAS）之间存在关联。其中一些研究描述的患者显示，GH水平升高可能导致呼吸驱动缺陷。肢端肥大症中出现的大多数全身性疾病都需要有效治疗。我们认为有必要通过检查睡眠中的呼吸障碍来进行有效治疗。
