Mezon B J, West P, MaClean J P, Kryger M H
Am J Med. 1980 Oct;69(4):615-8. doi: 10.1016/0002-9343(80)90477-5.
In patients with acromegaly obstruction of the upper airway may develop due to enlargement of the tongue and thickening of the tissues of the larynx. The sleep apnea syndrome may develop in patients with upper airway obstruction from other causes. We studied a somnolent patient with acromegaly in whom we documented the sleep apnea syndrome. Endoscopy, while the patient was sleeping, revealed that periodic obstruction during sleep occurred because the large tongue bulged into the pharynx and obliterated the pharyngeal airway. Tracheostomy was followed by the disappearance of the somnolence. The upper airway obstruction in acromegaly may result in severe hypoxemia and disruption of normal sleep.
在肢端肥大症患者中，由于舌头增大和喉部组织增厚，可能会出现上呼吸道梗阻。睡眠呼吸暂停综合征也可能发生于由其他原因导致上呼吸道梗阻的患者。我们研究了一名嗜睡的肢端肥大症患者，并记录了其睡眠呼吸暂停综合征。患者睡眠期间的内镜检查显示，睡眠期间周期性梗阻是因为大舌头突入咽部并阻塞了咽气道。气管切开术后嗜睡症状消失。肢端肥大症中的上呼吸道梗阻可能导致严重低氧血症和正常睡眠中断。
