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[结核病药物治疗的开始]

[Inicio del tratamiento farmacológico de la tuberculosis].

作者信息

Cicero-Sabido Raúl, Meléndez-Mier Guillermo

机构信息

Universidad Nacional Autónoma de México, Facultad de Medicina.

Secretaría de Salud, Hospital General de México, Dirección de Investigación, Ciudad de México, México.

出版信息

Gac Med Mex. 2018;154(5):620-621. doi: 10.24875/GMM.17003616.

Abstract

The appearance of new anti-tuberculosis drugs such as bedaquiline and delamanid makes it impossible not to remember that the first strictly controlled medical trials of tuberculosis treatment were published in two rigorously researched outstanding articles that can be qualified as historical. In 1948, streptomycin was formally studied as an efficacious anti-tuberculosis drug. In 1952, another trial compared streptomycin-paramino salicylic acid with isoniazid, by means of which the first bases of pharmacological tuberculosis treatment were established.

摘要

诸如贝达喹啉和地拉马尼等新型抗结核药物的出现,让人不禁想起,最早关于结核病治疗的严格对照医学试验发表在两篇经过严谨研究的杰出文章中,这两篇文章堪称具有历史意义。1948年,链霉素作为一种有效的抗结核药物得到正式研究。1952年,另一项试验将链霉素-对氨基水杨酸与异烟肼进行了比较,由此确立了结核病药物治疗的最初基础。

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