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13 价肺炎球菌结合疫苗实施 6 年后儿童社区获得性肺炎旁胸腔积液和脓胸的细菌病因变化。

Change in Bacterial Causes of Community-Acquired Parapneumonic Effusion and Pleural Empyema in Children 6 Years After 13-Valent Pneumococcal Conjugate Vaccine Implementation.

机构信息

Service de Pédiatrie, Centre Hospitalier Intercommunal, Créteil, France.

Université Paris Est, IMRB-GRC GEMINI, Créteil, France.

出版信息

J Pediatric Infect Dis Soc. 2019 Nov 6;8(5):474-477. doi: 10.1093/jpids/piy103.

DOI:10.1093/jpids/piy103
PMID:30407519
Abstract

We describe here changes in the bacterial causes of pleural empyema before and after implementation of the 13-valent pneumococcal conjugate vaccine (PCV13) program in France (2009-2017). For 220 (39.3%) of 560 children, a bacterial cause was found. The frequency of pneumococcal infection decreased during the study from 79.1% in 2009 to 36.4% in 2017 (P < .001). Group A streptococcus is now the leading cause of documented empyema (45.5%).

摘要

我们在此描述了法国（2009-2017 年）实施 13 价肺炎球菌结合疫苗（PCV13）计划前后，胸腔积脓性胸膜炎的细菌病因变化。在 560 名儿童中，有 220 名（39.3%）确定了细菌病因。在研究期间，肺炎球菌感染的频率从 2009 年的 79.1%下降到 2017 年的 36.4%（P<0.001）。A 组链球菌现在是有记录的脓胸的主要病因（45.5%）。

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