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2016 - 2022年哥伦比亚一家四级儿童医院对5岁以下儿童细菌性肺炎的哨点监测

Sentinel surveillance in bacterial pneumonia in children under 5 years old in a fourth-level pediatric hospital in Colombia 2016-2022.

作者信息

Camacho-Moreno Germán, Duarte Carolina, Perdomo María Del Pilar, Maldonado Luz Yaneth, Palacios Jacqueline, Rojas Jaid Constanza, Moreno Jaime, Jerez Daniela, Duarte María Cristina, Degraff Evelyn, Sanabria Olga, Sabogal Eliana, Bautista Adriana, Elizalde Yenny, Jimenez Karen

机构信息

HOMI, Fundación Hospital pediátrico de la Misericordia, Bogotá, Colombia.

Universidad Nacional de Colombia, Bogotá, Colombia.

出版信息

IJID Reg. 2024 Sep 17;13:100449. doi: 10.1016/j.ijregi.2024.100449. eCollection 2024 Dec.

Abstract

OBJECTIVES

Sentinel surveillance for bacterial pneumonia (SSBP) allows the monitoring of immunopreventable diseases. The results of the SSBP carried out at HOMI, Fundación Hospital pediátrico de la Misericordia, are presented.

METHODS

The daily active search for cases was carried out in accordance with the protocol of the Pan American Health Organization from January 2016 to December 2022.

RESULTS

There were 6970 suspected cases of bacterial pneumonia (BP). Among the 3048 (43.7%) patients with probable BP, cultures were obtained from 2777 (91.1%), and BP was confirmed in 190 (6.2%). The causes were in 98 (51.6%) cases, Spn19A in 47 (48%), Spn3 in 16 (16%), and Spn6C in 4 (4%). was found in 32 (16.8%) cases: non-typeable in 20 (62.5%), type b in five (15.6%), and type a in two (6.2%). Other bacteria were found in 60 (31.6%) cases. A total of 51.6% and 42.9% of patients with had decreased sensitivity to penicillin and ceftriaxone, respectively.

CONCLUSIONS

The serotypes included in the conjugate vaccines for pneumococcus and b decreased significantly, and serotype turnover was observed. Among the cases, Spn19A, Spn3, and Spn6C were the most frequent serotypes and associated with multiresistance. The SSBP allows us to determine the clinical behavior of the disease and to detect the serotypes emergence.

摘要

目的

细菌性肺炎哨点监测(SSBP)可对免疫可预防疾病进行监测。本文呈现了在慈悲儿童医院基金会(HOMI)开展的SSBP结果。

方法

2016年1月至2022年12月期间,按照泛美卫生组织的方案对病例进行每日主动搜索。

结果

有6970例疑似细菌性肺炎(BP)病例。在3048例(43.7%)可能患有BP的患者中,2777例(91.1%)进行了培养,确诊BP的有190例(6.2%)。病因方面,98例(51.6%)为某种菌,47例(48%)为Spn19A,16例(16%)为Spn3,4例(4%)为Spn6C。在32例(16.8%)病例中发现了另一种菌:20例(62.5%)为不可分型,5例(15.6%)为b型,2例(6.2%)为a型。60例(31.6%)病例中发现了其他细菌。分别有51.6%和42.9%的该种菌患者对青霉素和头孢曲松的敏感性降低。

结论

肺炎球菌结合疫苗和b型流感嗜血杆菌结合疫苗所包含的血清型显著减少,且观察到血清型更替。在该种菌病例中,Spn19A、Spn3和Spn6C是最常见的血清型且与多重耐药相关。SSBP使我们能够确定疾病的临床行为并检测血清型的出现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e45b/11490932/334b27136877/ga1.jpg

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