Marzlin Nathan, Dunbar Sara, Cinquegrani Michael
Medical College of Wisconsin, Milwaukee, Wisconsin,
Medical College of Wisconsin, Milwaukee, Wisconsin.
WMJ. 2018 Oct;117(4):175-176.
Platypnea-orthodeoxia syndrome is a rare clinical syndrome defined by worsening deoxygenation and dyspnea when changing to an upright sitting or standing position. It is seen in 3 different clinical scenarios: intracardiac shunts, pulmonary arteriovenous shunts, and ventilation/perfusion mismatch in the lungs.
An 82-year-old woman with a history of nonischemic cardiomyopathy with reduced ejection fraction was admitted with dyspnea and hypoxemia. She was found to have atrial septal defect with right to left shunting in the setting of normal right atrial pressures.
Platypnea-orthodeoxia syndrome is a clinical syndrome where, in the setting of an interatrial communication, a right to left shunt can occur without elevated pulmonary or right atrial pressure, resulting in significant hypoxia.
Platypnea-orthodeoxia syndrome is a clinical condition that is being recognized more frequently due to more accurate diagnosis, and its treatment can alleviate symptomatic hypoxemia.
平卧呼吸-直立性低氧血症综合征是一种罕见的临床综合征，其定义为在转变为直立坐姿或站立姿势时出现氧合恶化和呼吸困难。它见于3种不同的临床情况：心内分流、肺动静脉分流以及肺部通气/灌注不匹配。
一名82岁女性，有射血分数降低的非缺血性心肌病病史，因呼吸困难和低氧血症入院。她被发现存在房间隔缺损，在右心房压力正常的情况下有右向左分流。
平卧呼吸-直立性低氧血症综合征是一种临床综合征，在存在心房交通的情况下，可在不伴有肺或右心房压力升高的情况下发生右向左分流，从而导致严重缺氧。
平卧呼吸-直立性低氧血症综合征是一种由于诊断更加准确而被更频繁认识到的临床病症，其治疗可缓解症状性低氧血症。
