Akin E, Krüger U, Braun P, Stroh E, Janicke I, Rezwanian R, Akin I, Schöls W H
Herzzentrum Duisburg, Duisburg (Akademisches Lehrkrankenhaus der Heinrich-Heine-Universität Düsseldorf), Germany.
Eur Rev Med Pharmacol Sci. 2014;18(18):2599-604.
The platypnea orthodeoxia syndrome (POS) is a rare condition characterized by dyspnea and hypoxia in upright position. Pathopysiologic underlying mechanisms are determined by an atrial right-to-left shunt. Coexisting conditions that evolve POS can be of anatomical nature causing interatrial communication or of functional nature producing a deformity of the atrial septum in upright position. Diagnosis is difficult, as it needs to mention about POS. Classically, transthoracic and transesophageal echocardiography in supine and upright position with use of contrast medium and/or Doppler will point the diagnosis. Treatment is predominantly carried out by interventional closure of atrial septal defect that promptly resolves clinical symptoms.
平卧呼吸困难直立低氧血症综合征（POS）是一种罕见病症，其特征为直立位时出现呼吸困难和低氧血症。病理生理潜在机制由心房右向左分流决定。并发导致POS的情况可能是解剖学性质的，引起心房交通，或者是功能性的，导致直立位时房间隔畸形。诊断困难，因为需要提及POS。经典的方法是在仰卧位和直立位使用造影剂和/或多普勒进行经胸和经食管超声心动图检查来明确诊断。治疗主要通过介入性闭合房间隔缺损来进行，这能迅速缓解临床症状。
