Department of Neurology, West China Hospital of Sichuan University, Chengdu, China.
Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China.
J Neuroimmunol. 2018 Dec 15;325:64-68. doi: 10.1016/j.jneuroim.2018.10.013. Epub 2018 Nov 1.
Currently, no data are available regarding the expression levels of CD40L on CD4 T cells in patients with neuromyelitis optica spectrum disorders (NMOSD). The percentage of circulating CD40LCD4 T cells was measured by flow cytometry in 23 NMOSD patients and 10 healthy controls. The ratio of CD40LCD4 to CD4 T cells in patients at acute phase (18.28 ± 15.56%) was significantly higher than that in healthy controls (7.23 ± 5.94%, P = .032) and was positively correlated with disease severity (r = 0.532, P = .041). Thus, our results suggest an important role of this molecule in acute attacks of NMOSD.
目前，尚无关于视神经脊髓炎谱系疾病（NMOSD）患者 CD40L 在 CD4 T 细胞上的表达水平的数据。通过流式细胞术测量了 23 名 NMOSD 患者和 10 名健康对照者循环 CD40LCD4 T 细胞的百分比。急性期患者的 CD40LCD4/CD4 T 细胞比值（18.28±15.56%）明显高于健康对照组（7.23±5.94%，P=0.032），且与疾病严重程度呈正相关（r=0.532，P=0.041）。因此，我们的结果表明该分子在 NMOSD 的急性发作中起重要作用。
