Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China; University of Chinese Academy of Sciences, Beijing 100049, China.
College of Life Science and Technology, Xinjiang University, Urumqi 830046, China.
Phytochemistry. 2019 Jan;157:151-157. doi: 10.1016/j.phytochem.2018.10.018. Epub 2018 Nov 6.
Eight previously undescribed acyl atractyligenin and carboxyatractyligenin glycosides were isolated from whole Antennaria rosea subsp. confinis (Greene) R. J. Bayer (Compositae) [syn. Leontopodium leontopodioides (Willd.) Beauv. (Asteraceae)] plants and their structures were determined by spectroscopic and chemical methods. The compounds were trivially named leontopodiosides F-M. Seven of the compounds showed potent in vitro inhibitory activity toward pancreatic lipase with IC values ranging from 3.4 to 52.5 μM, suggesting that they participate in the previously observed effect this plant has in reducing triglyceride absorption in rats.
从全缘叶橐吾亚属近缘变种（Antennaria rosea subsp. confinis (Greene) R. J. Bayer）[同义名：Leontopodium leontopodioides (Willd.) Beauv.（菊科）]植物中分离得到 8 种以前未描述的酰基苍术苷和羧基苍术苷糖苷，并通过光谱和化学方法确定了它们的结构。这些化合物被简单地命名为 leontopodiosides F-M。其中 7 种化合物对胰脂肪酶具有很强的体外抑制活性，IC 值范围为 3.4 至 52.5 μM，表明它们参与了先前观察到的这种植物降低大鼠甘油三酯吸收的作用。
