College of Life Science and Technology, Xinjiang University, Urumqi 830046, China.
Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Fitoterapia. 2018 Oct;130:89-93. doi: 10.1016/j.fitote.2018.08.010. Epub 2018 Aug 23.
Three new glucosides of hydroquinone, monoterpene, and megastigmane, benzyl 2,5-dihydroxybenzoate 5-O-β-d-glucopyranoside (isotrichocarpin, 1), (2S,3R)-3,7-dimethyl-6-octene-1,2,3-triol 2-O-β-d-glucopyranoside (leontopodioside D, 4), and (6R,7R,8R,9S)-6,9-epoxy-7,8-dihydroxymegastigman-4-en-3-one 8-O-β-d-glucopyranoside (leontopodioside E, 7) were isolated from the whole herbs of Leontopodium leontopodioides (Willd.) Beauv. (Asteraceae), along with nebrodenside A (2), pungenin (3), betulalbuside A (5), geranyl O-β-d-glucopyranoside (6), and 3β-hydroxy-β-ionone 3-O-β-d-glucopyranoside (8). Their structure were determined by spectroscopic and chemical methods. All the known compounds were reported from this species for the first time. Compounds 2-6 showed potent in vitro pancreatic lipase inhibitory activity, suggesting their participation in the reductive effect of the herbs on triglyceride absorption.
从绵头雪莲花（Willd.）（菊科）的全草中分离得到了三种新的对苯二酚、单萜和大根香叶烯类葡萄糖苷，分别为：2,5-二羟基苯甲酸苄酯 5-O-β-D-吡喃葡萄糖苷（异土木香苷，1）、（2S，3R）-3，7-二甲基-6-辛烯-1，2，3-三醇 2-O-β-D-吡喃葡萄糖苷（菜蓟苦苷 D，4）和（6R，7R，8R，9S）-6，9-环氧-7，8-二羟基大根香叶烯-4-烯-3-酮 8-O-β-D-吡喃葡萄糖苷（菜蓟苦苷 E，7）。此外，还从该植物中分离得到了 nebrodenside A（2）、pungenin（3）、betulalbuside A（5）、香叶基 O-β-D-吡喃葡萄糖苷（6）和 3β-羟基-β-紫罗兰酮 3-O-β-D-吡喃葡萄糖苷（8）。通过光谱和化学方法确定了它们的结构。所有这些已知化合物均首次从该种植物中分离得到。化合物 2-6 对胰脂肪酶表现出很强的体外抑制活性，提示它们可能参与了该植物对甘油三酯吸收的还原作用。
