胰腺腺泡细胞癌病例报告及文献复习。
Pancreatic acinar cell carcinoma-case report and literature review.
机构信息
Department of hepatobiliary surgery, Beijing Chaoyang Hospital, Capital Medical University, 8 Gongti South Street, Chaoyang District, 100021, Beijing, China.
Department of general surgery, The 2nd Hospital of Chengde Medical College, Chengde Central Hospital, Chengde, Hebei province, China.
出版信息
BMC Cancer. 2018 Nov 8;18(1):1083. doi: 10.1186/s12885-018-5008-z.
BACKGROUND
Pancreatic acinar cell carcinoma (ACC) is a rare tumor that constitutes 1% of all pancreatic neoplasms. Pancreatic ACC has unique characteristics in terms of biological behavior, imaging and prognosis.
CASE PRESENTATION
The present study reported two cases of pancreatic ACC confirmed by postoperative pathology and both cases exhibited several different imaging features and laboratory test results. Both cases had approximately 4 cm mass located in uncinate process of pancreas. Dilated intra- and extra-hepatic bile ducts was observed in one case, along with calcification. Heterogeneous enhancement of the tumor was exhibited in both patients with different intensities. Obstructive jaundice, elevated α-fetoprotein and CA 19-9 was found in one case, while the other case had normal liver function and tumor markers.
CONCLUSIONS
It was difficult to accurately diagnose pancreatic ACC before the operation despite its unique characteristics. Radical resection was the best treatment modality for resectable pancreatic ACC.
背景
胰腺腺泡细胞癌（ACC）是一种罕见的肿瘤，约占所有胰腺肿瘤的 1%。胰腺 ACC 在生物学行为、影像学和预后方面具有独特的特征。
病例报告
本研究报道了两例经术后病理证实的胰腺 ACC 病例，这两例病例均表现出不同的影像学特征和实验室检查结果。两例患者均有约 4cm 大小的肿块位于胰腺钩突部。一例患者伴有胆管扩张和钙化，两例患者的肿瘤均表现为不均匀强化，强度不同。一例患者伴有阻塞性黄疸、甲胎蛋白和 CA 19-9 升高，另一例患者肝功能和肿瘤标志物正常。
结论
尽管胰腺 ACC 具有独特的特征，但在手术前仍难以准确诊断。对于可切除的胰腺 ACC，根治性切除术是最佳的治疗方式。
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