富含乙酰胆碱的茄子（茄子属）经口给药对自发性高血压大鼠的降压作用。

Antihypertensive effects of orally administered eggplant (Solanum melongena) rich in acetylcholine on spontaneously hypertensive rats.

机构信息

Department of Agriculture, Graduate School of Science and Technology, Shinshu University, 8304, Minamiminowa, Nagano 399-4598, Japan.

Wellnas. Co., Ltd., 508-2, Fii Building, 3-15-1, Tokida, Ueda, Nagano 386-8567, Japan.

出版信息

Food Chem. 2019 Mar 15;276:376-382. doi: 10.1016/j.foodchem.2018.10.017. Epub 2018 Oct 4.

DOI:10.1016/j.foodchem.2018.10.017

PMID:30409608

Abstract

Our previous results (Nakamura et al., 2013, 2016) indicated that acetylcholine (ACh) in orally administered foods exerts antihypertensive effects. Eggplants (Solanum melongena) contain abundant ACh (Horiuchi et al., 2003), and their food functionality was discovered, using spontaneously hypertensive rats, by measuring blood pressure after oral administration of a suspension of lyophilized eggplant powder. We found that lyophilized eggplant powder induced significantly lowered acute and chronic blood pressure levels at very low doses of 0.0650 mg/kg body weight (b.w.) and 0.821 mg/(kg b.w.·day), respectively. Chronic administration suppressed adrenaline and noradrenaline excretion in the urine, and aorta assays showed that eggplant acted on the M3 muscarinic ACh receptor (M3 mAChR). ACh was conclusively shown to function as the main component of eggplant contributing to antihypertensive activity by suppressing sympathetic nervous activity via M3 mAChR. This report reveals a new food functionality of eggplant and its potential as a novel antihypertensive food.

摘要

我们之前的研究结果（Nakamura 等人，2013 年，2016 年）表明，口服食物中的乙酰胆碱（ACh）具有降血压作用。茄子（Solanum melongena）含有丰富的 ACh（Horiuchi 等人，2003 年），我们使用自发性高血压大鼠，通过测量口服冻干茄子粉悬浮液后的血压，发现了茄子的这种食物功能。我们发现，低剂量的 0.0650mg/kg 体重（b.w.）和 0.821mg/（kg b.w.·day）的冻干茄子粉可显著降低急性和慢性血压水平。慢性给药抑制了肾上腺素和去甲肾上腺素在尿液中的排泄，主动脉试验表明，茄子通过 M3 毒蕈碱乙酰胆碱受体（M3 mAChR）作用于交感神经系统。通过 M3 mAChR 抑制交感神经活性，ACh 被确认为是茄子发挥降压活性的主要成分。本报告揭示了茄子的一种新的食物功能及其作为新型降压食品的潜力。