Bennett G W, Edwards R M, Lighton C, Marsden C A
J Recept Res. 1987;7(1-4):555-79. doi: 10.3109/10799898709055002.
This study investigates the effects of chemically lesioning 5-hydroxytryptamine (5HT) neurones and chronic passive immunization of central thyrotrophin releasing hormone (TRH) on 5HT and TRH mediated behavioural responses. 5HT lesions produced by 5,7-dihydroxytryptamine (5,7-DHT) enhanced the behavioural response produced by the 5HT receptor agonist 5-methoxy-N,N-dimethyltryptamine (5-MEODMT) while decreasing the locomotor hyperactivity observed following administration of the TRH analogue CG 3509 but having no effect on the reversal of pentobarbitone sleep-time produced by CG 3509. Chronic intracerebroventricular infusion of the purified TRH antibody markedly increased the length of pentobarbitone-induced sleep-time while enhancing the effects of CG 3509 both on locomotor activity and pentobarbitone-induced sleep. TRH antibody infusion also increased the response produced by 5-MEODMT. The results indicate that chronic passive immunization of central TRH induces changes in TRH receptor responsiveness and that there is a functional interaction between TRH and 5HT neuronal systems.
本研究调查了化学损伤5-羟色胺（5HT）神经元以及对中枢促甲状腺激素释放激素（TRH）进行慢性被动免疫对5HT和TRH介导的行为反应的影响。由5,7-二羟色胺（5,7-DHT）造成的5HT损伤增强了5HT受体激动剂5-甲氧基-N,N-二甲基色胺（5-MEODMT）产生的行为反应，同时减少了给予TRH类似物CG 3509后观察到的运动性多动，但对CG 3509所产生的戊巴比妥睡眠时间的逆转没有影响。慢性脑室内注入纯化的TRH抗体显著增加了戊巴比妥诱导的睡眠时间，同时增强了CG 3509对运动活性和戊巴比妥诱导睡眠的影响。注入TRH抗体也增加了5-MEODMT产生的反应。结果表明，对中枢TRH进行慢性被动免疫会诱导TRH受体反应性的变化，并且TRH和5HT神经元系统之间存在功能相互作用。
