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Chronic immunization of endogenous thyrotrophin-releasing hormone (TRH) in brain alters the behavioural response to pentobarbital and a TRH analogue.

作者信息

Lighton C, Bennett G W, Marsden C A

出版信息

Brain Res. 1986 Jul 23;378(2):385-9. doi: 10.1016/0006-8993(86)90942-x.

DOI:10.1016/0006-8993(86)90942-x
PMID:3089541
Abstract

Rats were infused with purified thyrotrophin-releasing hormone (TRH) anti-serum i.c.v. for two weeks and the reversal of pentobarbital-induced anaesthesia, hypothermia and respiratory depression by central administration of a TRH analogue (CG 3509) was measured. After antibody infusion the anaesthesia time was more than doubled but the responses to CG 3509 were increased, suggesting a role for endogenous TRH in arousal mechanisms which is sensitized following chronic immunological blockade.

摘要

相似文献

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Chronic immunization of endogenous thyrotrophin-releasing hormone (TRH) in brain alters the behavioural response to pentobarbital and a TRH analogue.
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