Palacios J M, Cortés R, Probst A
J Recept Res. 1987;7(1-4):581-97. doi: 10.3109/10799898709055003.
Receptor modifications in human postmortem material were studied by quantitative autoradiography. Alterations of several neurotransmitter receptors in neurodegenerative diseases such as senile dementia and Huntington's chorea, in lesions of specific brain pathways, like the visual pathway or after drug treatments, were examined. In all these situations alterions of the density or localization of receptors were seen using autoradiography. The results suggest that several mechanisms of receptor adaptation operate in the human brain. These mechanisms include: compensatory changes in receptor density as a consequence of cell loss, in some cases preceding the neuropathological changes; differential alterations in receptors depending on their location in a given pathway, for example in the visual pathway or selective homologous or heterologous modification of receptors after drug treatment.
通过定量放射自显影术研究了人类尸检材料中的受体修饰。研究了神经退行性疾病（如老年痴呆症和亨廷顿舞蹈症）、特定脑通路（如视觉通路）损伤或药物治疗后几种神经递质受体的变化。在所有这些情况下，使用放射自显影术都能观察到受体密度或定位的改变。结果表明，人类大脑中存在几种受体适应机制。这些机制包括：细胞丢失导致的受体密度代偿性变化，在某些情况下先于神经病理学变化；受体根据其在特定通路中的位置而发生的差异改变，例如在视觉通路中，或药物治疗后受体的选择性同源或异源修饰。
