Palacios J M, Cortés R, Dietl M, Probst A
Preclinical Research, Sandoz Ltd., Basle, Switzerland.
J Recept Res. 1988;8(1-4):509-20. doi: 10.3109/10799898809049008.
The application of the technique of in vitro receptor autoradiography to the study of neurotransmitter receptor alterations associated with human brain diseases is reviewed. Focus is made on receptor alterations in Parkinson's disease and Senile Dementia. Different types of modifications have been found. The most important are 1) receptor changes related to a specific neuronal loss; 2) receptor regulation associated with modifications of presynaptic input; 3) receptor changes which cannot directly be related to neuronal loss or presynaptic changes. The possible value as a diagnostic tool and the utility of receptor autoradiography in neuropathology is discussed.
本文综述了体外受体放射自显影技术在研究与人类脑部疾病相关的神经递质受体改变方面的应用。重点关注帕金森病和老年痴呆症中的受体改变。已发现不同类型的改变。最重要的有：1）与特定神经元丢失相关的受体变化；2）与突触前输入改变相关的受体调节；3）不能直接与神经元丢失或突触前变化相关的受体变化。还讨论了受体放射自显影作为诊断工具的可能价值及其在神经病理学中的应用。
