Tannen R L, Cordano A
J Pharmacol Exp Ther. 1978 Jan;204(1):240-6.
A slow-release tablet containing 12.5 mEq of potassium chloride was compared with a potassium chloride solution in normal human subjects under controlled conditions. Changes in plasma potassium concentration and rates of urinary potassium excretion indicate the tablet is absorbed in a slow, sustained fashion in contrast to the solution. Net potassium excretion after single and multiple doses indicates that the amount of potassium absorbed from the slow-release tablet is comparable to the solution. The slow-release potassium chloride tablets were well tolerated and were effective in correcting experimentally induced potassium depletion of moderate severity. Gastrointestinal tract irritation was not apparent and fecal 51Cr red blood cell loss after the tablet and the solution were of the same order.
在受控条件下，对含12.5毫当量氯化钾的缓释片与氯化钾溶液在正常人体受试者中进行了比较。血浆钾浓度的变化和尿钾排泄率表明，与溶液相比，该片剂以缓慢、持续的方式被吸收。单次和多次给药后的净钾排泄表明，从缓释片中吸收的钾量与溶液相当。缓释氯化钾片耐受性良好，对纠正实验性诱导的中度严重程度的钾缺乏有效。胃肠道刺激不明显，服用该片剂和溶液后粪便中51Cr红细胞损失情况相同。
