Lowance D C, Murad F, Darrow W R, Bonus L
Int J Clin Pharmacol Ther Toxicol. 1982 May;20(5):204-8.
The rate and extent of potassium absorption from a slow-release potassium chloride tablet and a 10% potassium chloride solution were compared in 12 healthy male volunteers, 18-25 years old. A single 48 mEq potassium dose of the tablet released potassium 30 min slower than the same dose of potassium chloride solution. Potassium was completely absorbed from both preparations within 24 h. Complete absorption was confirmed by quantitative determination of fecal potassium excretion. Gastrointestinal tolerance was good with both preparations, although the incidence of adverse experiences was slightly higher with the liquid preparation. "Bad taste" was not associated with the slow-release tablet; 92% of the subjects reported "bad taste" with the potassium chloride solution.
在12名年龄在18至25岁的健康男性志愿者中，比较了缓释氯化钾片和10%氯化钾溶液中钾的吸收速率和吸收程度。单剂量48毫当量的该片剂释放钾的时间比相同剂量的氯化钾溶液慢30分钟。两种制剂中的钾在24小时内均被完全吸收。通过定量测定粪便钾排泄量证实了完全吸收。两种制剂的胃肠道耐受性均良好，尽管液体制剂的不良事件发生率略高。“味道差”与缓释片无关；92%的受试者报告氯化钾溶液“味道差”。
