结晶试验在筛查潜在恶性口腔疾病和口腔癌中的有效性。
Effectiveness of crystallization test in screening of potentially malignant oral disorders and oral cancer.
作者信息
Tarigoppula Ratna Kumari V N, Ahmed Mujib B R, Naik Rashmi
机构信息
Department of Oral Pathology and Microbiology, Bapuji Dental College and Hospital, Davangere, Karnataka, India.
出版信息
Indian J Dent Res. 2018 Sep-Oct;29(5):556-561. doi: 10.4103/ijdr.IJDR_535_16.
AIM
This study aims to determine the effectiveness of crystallization test in screening of oral potentially malignant disorders (PMDs) and oral cancer.
MATERIALS AND METHODS
Thirty patients of oral PMD, 30 patients of oral cancer and 40 normal healthy people were selected. One drop of blood was collected and added to 1 cc of double-distilled water at room temperature to get a final dilution of 6% hemolyzed blood. 0.1-0.2 cc of this blood sample is added to 10 cc of 20% cupric chloride solution and further is subjected to crystallization test.
RESULTS
In the normal healthy group, the pattern was typical with an eccentrically placed center of gravity with needles arranged in radiating fashion. Whereas in oral PMD and cancer groups, there was "transverse form" formation. This test had sensitivity and specificity of about 83.33% and 86.84% for PMDs group and 96.30% and 86.84% for oral cancer group respectively.
CONCLUSION
Crystallization test was found to be sensitive, reliable, economical and less-invasive procedure for screening of oral PMDs and oral cancer.
目的
本研究旨在确定结晶试验在筛查口腔潜在恶性疾病（PMD）和口腔癌方面的有效性。
材料与方法
选取30例口腔PMD患者、30例口腔癌患者和40名正常健康人。采集一滴血液，在室温下加入1毫升双蒸水，最终得到6%溶血血液稀释液。将0.1 - 0.2毫升该血液样本加入10毫升20%氯化铜溶液中，进一步进行结晶试验。
结果
在正常健康组中，结晶模式典型，重心偏心放置，针呈放射状排列。而在口腔PMD组和癌症组中，出现了“横向形态”。该试验对PMD组的敏感性和特异性分别约为83.33%和86.84%，对口腔癌组分别为96.30%和86.84%。
结论
结晶试验被发现是一种用于筛查口腔PMD和口腔癌的敏感、可靠、经济且侵入性较小的方法。
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