Brinckerhoff C E
J Rheumatol. 1987 May;14 Spec No:61-3.
The metalloproteinase collagenase that is synthesized and secreted by synovial cells is responsible for the large amount of connective tissue destruction seen in rheumatoid arthritis. We have used a model system of cultured rabbit synovial fibroblasts to better understand mechanisms controlling both the induction and suppression of collagenase synthesis. Induction of collagenase requires an increase in collagenase mRNA and concomitantly, suppression of collagenase synthesis by retinoids and glucocorticoids is accompanied by a decrease in collagenase mRNA. Another metalloproteinase, activator, which is responsible for the activation of latent procollagenase and which has gelatinolytic ability, is coordinately regulated with collagenase. We conclude that there may exist a family of metalloproteinases that is important in the modulation of connective tissues and that is coordinately regulated at the level of mRNA.
由滑膜细胞合成并分泌的金属蛋白酶胶原酶，是类风湿性关节炎中大量结缔组织破坏的原因。我们利用培养的兔滑膜成纤维细胞模型系统，以更好地理解控制胶原酶合成诱导和抑制的机制。胶原酶的诱导需要胶原酶信使核糖核酸（mRNA）增加，同时，类视黄醇和糖皮质激素对胶原酶合成的抑制伴随着胶原酶mRNA的减少。另一种金属蛋白酶——激活剂，负责激活潜在的前胶原酶且具有明胶分解能力，它与胶原酶协同调节。我们得出结论，可能存在一个金属蛋白酶家族，其在结缔组织的调节中很重要，并且在信使核糖核酸水平上受到协同调节。
