J Thorac Cardiovasc Surg. 1987 Sep;94(3):349-54.
The disease-free, postresection, 2 year survival rate of patients with T1 N0 non-small cell lung cancer surgically/pathologically staged by the Lung Cancer Study Group is about 82%. This study of the rate of cancer recurrence and histopathologic types is based on 572 eligible patients who submitted to complete resection of T1 N0 lung cancer and rigorous, systematic mediastinal lymph node sampling. The initial pathologic interpretation and staging were reviewed by pathologists of the Lung Cancer Study Group Pathology Reference Center to assure uniformity. Review was completed for 82% of patients included in this report. Postoperative cancer recurrence was observed in 107 of the 572 eligible patients. Histopathologic classification was squamous carcinoma (226 patients) or nonsquamous, non-small cell carcinoma (346 patients). Cancer recurrences are more frequent and recurrence rates are higher in the patients with nonsquamous cancer. There is a greater probability of first recurrence in the brain in the nonsquamous carcinoma group. This study substantiates the observation that lung cancer recurrences are histopathologically dependent in the T1 N0 subgroup of Stage I non-small cell lung cancer, with higher rates occurring among patients with nonsquamous carcinoma.
由肺癌研究组进行手术/病理分期的T1 N0非小细胞肺癌患者的无病、切除术后2年生存率约为82%。这项关于癌症复发率和组织病理学类型的研究基于572例符合条件的患者，这些患者均接受了T1 N0肺癌的完整切除及严格、系统的纵隔淋巴结采样。肺癌研究组病理参考中心的病理学家对初始病理诊断和分期进行了审核，以确保一致性。本报告中82%的患者完成了审核。572例符合条件的患者中有107例出现术后癌症复发。组织病理学分类为鳞状癌（226例患者）或非鳞状非小细胞癌（346例患者）。非鳞状癌患者的癌症复发更频繁，复发率更高。非鳞状癌组首次复发于脑部的可能性更大。这项研究证实了以下观察结果：在I期非小细胞肺癌的T1 N0亚组中，肺癌复发在组织病理学上具有依赖性，非鳞状癌患者的复发率更高。
