Zhang Xiangwei, Wang Yang, Jiang Yuanzhu, Wang Zhaoyang, Zhao Linping, Xue Xianbiao, Sang Shaowei, Zhang Lin
Department of Thoracic Surgery.
Department of Medical Imaging, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan.
Medicine (Baltimore). 2018 Oct;97(43):e12902. doi: 10.1097/MD.0000000000012902.
More and more studies were performed to explore the prognostic role of tumor length in esophageal cancer (EC). However, the results remain controversial. Hence, the aim of the review was to evaluate the association between tumor length and oncologic outcome in EC patients through meta-analysis.
A systematic literature search for relevant articles published in English language will be conducted in the PubMed, Web of Science, and Embase. Hazard ratio and 95% confidence intervals (CIs) will be employed as effect measures to estimate the correlation between tumor length and the oncologic outcomes including overall survival, disease-free survival, progression-free survival, relapse-free survival, and cancer-specific survival. We will use the software STATA 14.0 to perform the meta-analysis to calculate the data synthesis.
The review will provide a high-quality synthesis of current evidence of the prognostic role of tumor length in ECs. The results will be published in a peer-reviewed journal.
This will be the first systematic review and meta-analysis to evaluate the prognostic role of tumor length in EC patients. The results will better predict EC survival and identify higher-risk patients for postoperative therapy.
This systematic review protocol has been registered in the PROSPERO network (No. CRD42018106851).
越来越多的研究致力于探索肿瘤长度在食管癌（EC）中的预后作用。然而，结果仍存在争议。因此，本综述的目的是通过荟萃分析评估EC患者肿瘤长度与肿瘤学结局之间的关联。
将在PubMed、科学网和Embase中对以英文发表的相关文章进行系统的文献检索。风险比和95%置信区间（CIs）将用作效应量，以估计肿瘤长度与包括总生存、无病生存、无进展生存、无复发生存和癌症特异性生存在内的肿瘤学结局之间的相关性。我们将使用STATA 14.0软件进行荟萃分析以计算数据合成。
本综述将对目前关于肿瘤长度在EC中预后作用的证据进行高质量的综合分析。结果将发表在同行评审期刊上。
这将是第一项评估肿瘤长度在EC患者中预后作用的系统综述和荟萃分析。结果将能更好地预测EC的生存情况，并识别出术后治疗的高风险患者。
PROSPERO注册号：本系统综述方案已在PROSPERO网络中注册（编号CRD42018106851）。
