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Quantification of eicosanoids and their metabolites in biological matrices: a review.生物基质中类二十烷酸及其代谢物的定量分析：综述
Bioanalysis. 2018 Dec;10(24):2027-2046. doi: 10.4155/bio-2018-0173. Epub 2018 Nov 6.
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Liquid chromatography-tandem mass spectrometry for the analysis of eicosanoids and related lipids in human biological matrices: a review.液相色谱-串联质谱法分析人体生物基质中的类二十烷酸及相关脂质：综述
J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 1;964:1-11. doi: 10.1016/j.jchromb.2014.01.046. Epub 2014 Feb 8.
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HPLC/MS/MS-based approaches for detection and quantification of eicosanoids.基于高效液相色谱/串联质谱法的类花生酸检测与定量方法。
Methods Mol Biol. 2009;579:161-87. doi: 10.1007/978-1-60761-322-0_8.
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Analysis of eicosanoids by LC-MS/MS and GC-MS/MS: a historical retrospect and a discussion.采用液相色谱-串联质谱法和气相色谱-串联质谱法分析类二十烷酸：历史回顾与探讨
J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 1;964:79-88. doi: 10.1016/j.jchromb.2014.03.017. Epub 2014 Mar 21.
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Liquid chromatography-tandem mass spectrometry analysis of eicosanoids and related compounds in cell models.细胞模型中类二十烷酸及相关化合物的液相色谱-串联质谱分析
J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 1;964:41-9. doi: 10.1016/j.jchromb.2014.05.024. Epub 2014 May 24.
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A Simple and Highly Sensitive Quantitation of Eicosanoids in Biological Samples Using Nano-flow Liquid Chromatography/Mass Spectrometry.使用纳流液相色谱/质谱法对生物样品中的类花生酸进行简单且高灵敏度的定量分析。
Anal Sci. 2018;34(2):177-182. doi: 10.2116/analsci.34.177.
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Simultaneous profiling and quantification of 25 eicosanoids in human serum by ultrahigh-performance liquid chromatography coupled to tandem mass spectrometry.采用超高效液相色谱-串联质谱法同时分析人血清中 25 种类二十烷酸。
Anal Bioanal Chem. 2022 Dec;414(29-30):8233-8244. doi: 10.1007/s00216-022-04351-6. Epub 2022 Nov 8.
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Highly sensitive and specific derivatization strategy to profile and quantitate eicosanoids by UPLC-MS/MS.通过 UPLC-MS/MS 进行衍生化策略，以高灵敏度和特异性对类二十烷酸进行分析和定量。
Anal Chim Acta. 2017 Jan 15;950:108-118. doi: 10.1016/j.aca.2016.10.046. Epub 2016 Nov 15.
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Ferromagnetic particles as a rapid and robust sample preparation for the absolute quantification of seven eicosanoids in human plasma by UHPLC-MS/MS.铁磁颗粒作为一种快速且可靠的样品制备方法，用于通过超高效液相色谱-串联质谱法对人血浆中的七种类二十烷酸进行绝对定量。
J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jun 1;1022:173-182. doi: 10.1016/j.jchromb.2016.03.022. Epub 2016 Mar 21.
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Development of a high-throughput ultra performance liquid chromatography-mass spectrometry assay to profile 18 eicosanoids as exploratory biomarkers for atherosclerotic diseases.建立一种高通量超高效液相色谱-质谱联用分析方法，以分析 18 种类二十烷酸作为动脉粥样硬化疾病的探索性生物标志物。
J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Oct 1;936:25-32. doi: 10.1016/j.jchromb.2013.08.001. Epub 2013 Aug 7.
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[Determination of three metabolites of thromboxane A and 8-iso-prostaglandin F in urine by ultra performance liquid chromatography-tandem mass spectrometry].超高效液相色谱-串联质谱法测定尿液中血栓素A和8-异前列腺素F的三种代谢物
Se Pu. 2025 Feb;43(2):148-154. doi: 10.3724/SP.J.1123.2024.02004.
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The Octadecanoids: Synthesis and Bioactivity of 18-Carbon Oxygenated Fatty Acids in Mammals, Bacteria, and Fungi.十八烷类化合物：哺乳动物、细菌和真菌中含18个碳原子的含氧脂肪酸的合成与生物活性
Chem Rev. 2025 Jan 8;125(1):1-90. doi: 10.1021/acs.chemrev.3c00520. Epub 2024 Dec 16.
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Pharmaceutical Modulation of Intracranial Aneurysm Development and Rupture.颅内动脉瘤发生与破裂的药物调控
J Clin Med. 2024 Jun 5;13(11):3324. doi: 10.3390/jcm13113324.
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Urinary eicosanoid levels in early life and risk of atopic disease in childhood.儿童期特应性疾病与生命早期尿类二十烷酸水平的相关性研究
J Allergy Clin Immunol. 2024 Sep;154(3):670-678. doi: 10.1016/j.jaci.2024.05.022. Epub 2024 Jun 1.
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Urinary Prostaglandin E2 Excretion and the Risk of Cardiovascular and Kidney Disease.尿前列腺素E2排泄与心血管疾病和肾脏疾病风险
J Am Heart Assoc. 2024 Feb 20;13(4):e032835. doi: 10.1161/JAHA.123.032835. Epub 2024 Feb 16.
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Impact of Selected Eicosanoids in Normal and Pathological Pregnancies.特定类花生酸在正常及病理妊娠中的影响
J Clin Med. 2023 Sep 15;12(18):5995. doi: 10.3390/jcm12185995.
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P2X signaling influences the production of pro-resolving and pro-inflammatory lipid mediators in alveolar macrophages derived from individuals with asthma.P2X 信号转导影响哮喘患者肺泡巨噬细胞中促分解代谢和促炎脂质介质的产生。
Am J Physiol Lung Cell Mol Physiol. 2023 Oct 1;325(4):L399-L410. doi: 10.1152/ajplung.00070.2023. Epub 2023 Aug 15.
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Prostaglandin E2, Osmoregulation, and Disease Progression in Autosomal Dominant Polycystic Kidney Disease.前列腺素 E2、渗透压调节和常染色体显性多囊肾病的疾病进展。
Clin J Am Soc Nephrol. 2023 Nov 1;18(11):1426-1434. doi: 10.2215/CJN.0000000000000269. Epub 2023 Aug 14.
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Development of SFC-MS Method for Quantification of Eicosanoids Biosynthesized in Primary Human Blood Cells.用于定量原发性人类血细胞中生物合成的类花生酸的超临界流体色谱-质谱联用方法的开发
Metabolites. 2022 Nov 30;12(12):1198. doi: 10.3390/metabo12121198.
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Simultaneous profiling and quantification of 25 eicosanoids in human serum by ultrahigh-performance liquid chromatography coupled to tandem mass spectrometry.采用超高效液相色谱-串联质谱法同时分析人血清中 25 种类二十烷酸。
Anal Bioanal Chem. 2022 Dec;414(29-30):8233-8244. doi: 10.1007/s00216-022-04351-6. Epub 2022 Nov 8.
本文引用的文献
1
An improved Ultra-High Performance Liquid chromatography-tandem mass spectrometry method for simultaneous quantitation of cytochrome P450 metabolites of arachidonic acid in human plasma.一种改良的超高效液相色谱-串联质谱法，用于同时定量人血浆中环氧化酶 P450 代谢物花生四烯酸。
J Chromatogr A. 2018 Aug 17;1563:144-153. doi: 10.1016/j.chroma.2018.05.072. Epub 2018 Jun 4.
2
Letter by Mitchell et al Regarding Article, "Urinary Prostaglandin Metabolites: An Incomplete Reckoning and a Flush to Judgment".米切尔等人就题为《尿前列腺素代谢产物：不完整的评估与仓促的判断》的文章所写的信。
Circ Res. 2018 May 11;122(10):e84-e85. doi: 10.1161/CIRCRESAHA.118.312976.
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Alterations of eicosanoids and related mediators in patients with schizophrenia.精神分裂症患者中类二十烷酸及其相关介质的改变。
J Psychiatr Res. 2018 Jul;102:168-178. doi: 10.1016/j.jpsychires.2018.04.002. Epub 2018 Apr 5.
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Mass spectrometry profiling reveals altered plasma levels of monohydroxy fatty acids and related lipids in healthy humans after controlled exposure to biodiesel exhaust.质谱分析显示，在健康人受控接触生物柴油废气后，血浆中单羟基脂肪酸和相关脂质的水平发生改变。
Anal Chim Acta. 2018 Aug 14;1018:62-69. doi: 10.1016/j.aca.2018.02.032. Epub 2018 Feb 20.
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Measurement of Serum and Hepatic Eicosanoids by Liquid Chromatography Tandem-Mass Spectrometry (LC-MS/MS) in a Mouse Model of Hepatocellular Carcinoma (HCC) with Delivery of c-Met and Activated β-Catenin by Hepatocyte Hydrodynamic Injection.采用液质联用（LC-MS/MS）技术测定肝癌（HCC）小鼠模型中经肝细胞液流注射递送的 c-Met 和激活的 β-连环蛋白的血清和肝内类二十烷酸。
Med Sci Monit. 2018 Mar 21;24:1670-1679. doi: 10.12659/msm.908931.
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Development and application of a UHPLC-MS/MS metabolomics based comprehensive systemic and tissue-specific screening method for inflammatory, oxidative and nitrosative stress.建立并应用基于 UHPLC-MS/MS 的代谢组学方法全面系统及组织特异性筛选炎症、氧化及硝化应激相关生物标志物
Anal Bioanal Chem. 2018 Apr;410(10):2551-2568. doi: 10.1007/s00216-018-0912-2. Epub 2018 Mar 2.
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Analysis of eicosanoid oxidation products in Alzheimer brain by LC-MS with uniformly 13C-labeled internal standards.采用 LC-MS 结合均 13C 标记内标分析阿尔茨海默病脑内的类二十烷酸氧化产物。
Free Radic Biol Med. 2018 Apr;118:108-118. doi: 10.1016/j.freeradbiomed.2018.02.019. Epub 2018 Feb 21.
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Ultra-Performance Liquid Chromatography-Mass Spectrometry Analysis of Free and Esterified Oxygenated Derivatives from Docosahexaenoic Acid in Rat Brain.大鼠脑中二十二碳六烯酸游离及酯化氧化衍生物的超高效液相色谱-质谱分析
Lipids. 2018 Jan;53(1):103-116. doi: 10.1002/lipd.12006. Epub 2018 Feb 22.
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Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A Proves Renal Origins of Urinary PGI-M and TX-M.患者缺乏细胞质磷脂酶 A 的情况下进行肾移植，证实尿 PGI-M 和 TX-M 的肾来源。
Circ Res. 2018 Feb 16;122(4):555-559. doi: 10.1161/CIRCRESAHA.117.312144. Epub 2018 Jan 3.
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Sensitive mass spectrometric assay for determination of 15-deoxy-Δ-prostaglandin J and its application in human plasma samples of patients with diabetes.用于测定15-脱氧-Δ-前列腺素J的灵敏质谱分析法及其在糖尿病患者人血浆样本中的应用。
Anal Bioanal Chem. 2018 Jan;410(2):521-528. doi: 10.1007/s00216-017-0748-1. Epub 2017 Nov 16.
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